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Gene Name, symbol, description:      RefSeq Number:   
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RTē Profiler™ PCR Array Pathway-Focused qRT-PCR Based Expression Profiling
RTē qPCR Primer Assay Gene-Specific Primers for qRT-PCR, Genome-Wide Availability
Cignal™ Pathway Reporter Assays Cell-Based Assays for Rapidly Analyzing Pathway Signaling Activity
miScript miRNA PCR Array miScript miRNA PCR Array
Multi-Analyte Profiler ELISArray Kits Analyze 12 Cytokines or Chemokines Simultaneously Using ELISA
Single Analyte ELISArray Kits High Performance ELISA with the Best Possible Antibodies
EpiTect Methyl II PCR Arrays Pathway-Focused PCR Based DNA Methylation Analysis
EpiTect Methyl II PCR Primer Assay PCR Assays for DNA Methylation Analysis, Genome-Wide Availability
SureSilencing™ shRNA Gene-Specific Plasmid-Based RNA Interference, Genome-Wide Availability
EpiTect ChIP qPCR Arrays Pathway-Focused qPCR Based Histone Modifications Analysis
        
Search Result: 75 gene(s) found matching 'HLA-DRB7'
Gene Symbol: STK19 (Human)Other Aliases: D6S60, D6S60E, G11, HLA-RP1, RP1
Refseq IDs: NM_004197, NM_032454, NR_026717, ENST00000375331, ENST00000375333, ENST00000460018, ENST00000463823, ENST00000466132, ENST00000466336, ENST00000469907, ENST00000471028, ENST00000473983, ENST00000478486, ENST00000479644, ENST00000483801, ENST00000484540, ENST00000490822, ENST00000491861, ENST00000492583, ENST00000519179
Description: Serine/threonine kinase 19
This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.
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Gene Symbol: RFX5 (Human)Other Aliases:
Refseq IDs: NM_000449, NM_001025603, XM_005245405, XM_005245406, XM_005245407, XM_005245408, XM_005245409, ENST00000290524, ENST00000368870, ENST00000392746, ENST00000412774, ENST00000421986, ENST00000422595, ENST00000430227, ENST00000435314, ENST00000436271, ENST00000436637, ENST00000437327, ENST00000444392, ENST00000450506, ENST00000452456, ENST00000452513, ENST00000452671, ENST00000458484, ENST00000469513, ENST00000475144, ENST00000478564, ENST00000479681, ENST00000494217
Description: Regulatory factor X, 5 (influences HLA class II expression)
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
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Gene Symbol: RFX4 (Human)Other Aliases: NYD-SP10
Refseq IDs: NM_032491, NM_002920, NM_213594, NM_001206691, XM_005269067, XM_005269068, XM_005269069, ENST00000229387, ENST00000357881, ENST00000392842, ENST00000536688, ENST00000536722, ENST00000539967, ENST00000546882, ENST00000549040, ENST00000551640, ENST00000552773, ENST00000552866, ENST00000552917
Description: Regulatory factor X, 4 (influences HLA class II expression)
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.
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Gene Symbol: RFX3 (Human)Other Aliases:
Refseq IDs: NM_002919, NM_134428, NM_001282116, NM_001282117, XM_005251534, XM_005251535, XM_005251536, XM_005251537, XM_005251538, XM_005251539, XM_005251540
Description: Regulatory factor X, 3 (influences HLA class II expression)
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.
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Gene Symbol: RFX2 (Human)Other Aliases:
Refseq IDs: NM_000635, NM_134433, XM_005259611, XM_005259612, ENST00000303657, ENST00000359161, ENST00000585324, ENST00000586302, ENST00000586806, ENST00000586940, ENST00000587181, ENST00000587321, ENST00000587700, ENST00000588021, ENST00000589340, ENST00000589523, ENST00000589641, ENST00000589712, ENST00000589742, ENST00000590778, ENST00000590822, ENST00000592172, ENST00000592281, ENST00000592337, ENST00000592473, ENST00000592546, ENST00000592883, ENST00000593241
Description: Regulatory factor X, 2 (influences HLA class II expression)
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.
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Gene Symbol: RFX1 (Human)Other Aliases: EFC, RFX
Refseq IDs: NM_002918, ENST00000254325, ENST00000586913, ENST00000588520, ENST00000588885, ENST00000589239, ENST00000589760, ENST00000589937
Description: Regulatory factor X, 1 (influences HLA class II expression)
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
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Gene Symbol: KIAA0020 (Human)Other Aliases: HA-8, HLA-HA8, PEN, PUF6, XTP5, hPUF-A
Refseq IDs: NM_014878, XM_005251635, ENST00000382032, ENST00000397885, ENST00000469168, ENST00000490444
Description: KIAA0020
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Gene Symbol: IK (Human)Other Aliases: CSA2, RED
Refseq IDs: NM_006083, ENST00000417647, ENST00000502899, ENST00000503332, ENST00000507593, ENST00000508301, ENST00000512827, ENST00000513256, ENST00000515015, ENST00000515592, ENST00000523672
Description: IK cytokine, down-regulator of HLA II
The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2.
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Gene Symbol: HMHB1 (Human)Other Aliases: HB-1, HLA-HB1
Refseq IDs: NM_021182
Description: Histocompatibility (minor) HB-1
This gene encodes one of the minor histocompatibility antigens, which play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human histocompatibility leukocyte antigen (HLA)-identical allogeneic bone marrow transplantation (BMT). This gene is only expressed in B cell acute lymphoblastic leukemia cells and Epstein-Barr virus-transformed B cells. The translation of this mRNA initiates at a non-AUG (CUG) codon.
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Gene Symbol: HMHA1 (Human)Other Aliases: ARHGAP45, HA-1, HLA-HA1
Refseq IDs: NM_012292, NM_001258328, NM_001282334, NM_001282335, NR_047652, ENST00000313093, ENST00000536472, ENST00000539243, ENST00000543365, ENST00000586033, ENST00000586378, ENST00000586866, ENST00000586937, ENST00000587186, ENST00000587602, ENST00000590214, ENST00000590512, ENST00000590577, ENST00000591169, ENST00000591293, ENST00000592297, ENST00000592335
Description: Histocompatibility (minor) HA-1
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Gene Symbol: HLA-W (Human)Other Aliases: HLA-W
Refseq IDs: ENST00000439514
Description: Major histocompatibility complex, class I, W (pseudogene) [Source:HGNC Symbol;Acc:23425]
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Gene Symbol: HLA-T (Human)Other Aliases: HLA-T
Refseq IDs: ENST00000429813
Description: Major histocompatibility complex, class I, T (pseudogene) [Source:HGNC Symbol;Acc:23478]
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Gene Symbol: HLA-P (Human)Other Aliases: HLA-P
Refseq IDs: ENST00000568192
Description: Major histocompatibility complex, class I, P (pseudogene) [Source:HGNC Symbol;Acc:21196]
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Gene Symbol: HLA-L (Human)Other Aliases: HLA-L
Refseq IDs: ENST00000420110, ENST00000463348, ENST00000482052, NR_027822
Description: Major histocompatibility complex, class I, L (pseudogene)
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Gene Symbol: HLA-K (Human)Other Aliases: HLA-K
Refseq IDs: ENST00000430151
Description: Major histocompatibility complex, class I, K (pseudogene) [Source:HGNC Symbol;Acc:4969]
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Gene Symbol: HLA-J (Human)Other Aliases: CDA12, D6S203, HLA-59, HLA-CDA12
Refseq IDs: NR_024240, ENST00000462773, ENST00000469281, ENST00000494367, ENST00000495278
Description: Major histocompatibility complex, class I, J (pseudogene)
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Gene Symbol: HLA-H (Human)Other Aliases: HLA-H
Refseq IDs: ENST00000383326, ENST00000383620, NR_001434
Description: Major histocompatibility complex, class I, H (pseudogene)
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Gene Symbol: HLA-G (Human)Other Aliases: MHC-G
Refseq IDs: NM_002127, XM_003960994, XM_005249055, XM_005249056, XM_005249057, XM_005249058, XM_005272810, XM_005274964, XM_005274965, XM_005274966, XM_005274967, XM_005275119, XM_005275120, XM_005275121, XM_005275122, XM_005275246, XM_005275247, XM_005275248, XM_005275249, XM_005275394, XM_005275549, XM_005275550, XM_005275551, XM_005275552, XR_241896, XR_246963, XR_247353, XR_247370, XR_247389, XR_247402, XR_247423, ENST00000360323, ENST00000376815, ENST00000376818, ENST00000376828, ENST00000428701, ENST00000478355, ENST00000478519
Description: Major histocompatibility complex, class I, G
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
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Gene Symbol: HLA-F-AS1 (Human)Other Aliases:
Refseq IDs: NR_026972, NR_026973, ENST00000399247, ENST00000434086, ENST00000458236
Description: HLA-F antisense RNA 1 (non-protein coding)
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Gene Symbol: HLA-F (Human)Other Aliases: CDA12, HLA-5.4, HLA-CDA12, HLAF
Refseq IDs: NM_018950, NM_001098478, NM_001098479, XM_005249053, XM_005249054, XM_005272809, XM_005274957, XM_005274958, XM_005274959, XM_005274960, XM_005274961, XM_005274962, XM_005274963, XM_005275112, XM_005275113, XM_005275114, XM_005275115, XM_005275116, XM_005275117, XM_005275118, XM_005275387, XM_005275388, XM_005275389, XM_005275390, XM_005275391, XM_005275392, XM_005275393, XM_005275547, XM_005275548, ENST00000259951, ENST00000334668, ENST00000376861, ENST00000414333, ENST00000429294, ENST00000434407, ENST00000440587, ENST00000444621, ENST00000462777, ENST00000465459, ENST00000475996, ENST00000482257, ENST00000484704, ENST00000485513, ENST00000486194, ENST00000489502, ENST00000606273
Description: Major histocompatibility complex, class I, F
HLA-F belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-F binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 42 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. The HLA-F gene exhibits few polymorphisms.
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Gene Symbol: HLA-E (Human)Other Aliases: EA1.2, EA2.1, HLA-6.2, MHC, QA1
Refseq IDs: NM_005516, ENST00000376630, ENST00000484194, ENST00000493699
Description: Major histocompatibility complex, class I, E
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
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Gene Symbol: HLA-DRB9 (Human)Other Aliases: HLA-DRB9
Refseq IDs: ENST00000449413
Description: Major histocompatibility complex, class II, DR beta 9 (pseudogene) [Source:HGNC Symbol;Acc:4957]
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Gene Symbol: HLA-DRB6 (Human)Other Aliases:
Refseq IDs: NR_001298, ENST00000411500, ENST00000437183, ENST00000437650, ENST00000440876
Description: Major histocompatibility complex, class II, DR beta 6 (pseudogene)
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Gene Symbol: HLA-DRB5 (Human)Other Aliases: HLA-DRB
Refseq IDs: NM_002125
Description: Major histocompatibility complex, class II, DR beta 5
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
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Gene Symbol: HLA-DRB4 (Human)Other Aliases: DR-4, DR4, DRB4, HLA-DR4B
Refseq IDs: NM_021983, XR_247369, XR_247388, XR_247422
Description: Major histocompatibility complex, class II, DR beta 4
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Gene Symbol: HLA-DRB3 (Human)Other Aliases: HLA-DR3B
Refseq IDs: NM_022555, XM_003846462, XM_005274907
Description: Major histocompatibility complex, class II, DR beta 3
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Gene Symbol: HLA-DRB1 (Human)Other Aliases: DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1
Refseq IDs: NM_002124, NM_001243965
Description: Major histocompatibility complex, class II, DR beta 1
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Gene Symbol: HLA-DRA (Human)Other Aliases: HLA-DRA1, MLRW
Refseq IDs: NM_019111, XM_005249052, XM_005272808, XM_005274956
Description: Major histocompatibility complex, class II, DR alpha
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
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Gene Symbol: HLA-DQB3 (Human)Other Aliases: HLA-DQB3
Refseq IDs: ENST00000425319
Description: Major histocompatibility complex, class II, DQ beta 3 [Source:HGNC Symbol;Acc:4946]
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Gene Symbol: HLA-DQB2 (Human)Other Aliases: HLA-DQB1, HLA-DXB
Refseq IDs: NR_003937, NM_001198858, XM_005249051, XM_005272807, XM_005274855, XM_005274955, XM_005275111, XM_005275245, XM_005275386, XM_005275546
Description: Major histocompatibility complex, class II, DQ beta 2
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Gene Symbol: HLA-DQB1-AS1 (Human)Other Aliases: HLA-DQB1-AS1
Refseq IDs: ENST00000419852
Description: HLA-DQB1 antisense RNA 1 [Source:HGNC Symbol;Acc:39762]
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Gene Symbol: HLA-DQB1 (Human)Other Aliases: CELIAC1, HLA-DQB, IDDM1
Refseq IDs: NM_002123, NM_001243961, NM_001243962, ENST00000374943, ENST00000399079, ENST00000399082, ENST00000399084, ENST00000434651, ENST00000460185, ENST00000484729, ENST00000487676
Description: Major histocompatibility complex, class II, DQ beta 1
HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
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Gene Symbol: HLA-DQA2 (Human)Other Aliases: DX-ALPHA, HLA-DXA
Refseq IDs: NM_020056, XM_005249050, XM_005272806, XM_005274854, XM_005275110, XM_005275385, XM_005275545
Description: Major histocompatibility complex, class II, DQ alpha 2
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Gene Symbol: HLA-DQA1 (Human)Other Aliases: CD, CELIAC1, DQ-A1, GSE, HLA-DQA
Refseq IDs: NM_002122, XM_003846467, XM_003846468, XM_005249049, XM_005274953, XM_005274954, XM_005275108, XM_005275109, XM_005275332, XM_005275333, XM_005275542, XM_005275543, XM_005275544, ENST00000343139, ENST00000374949, ENST00000395363, ENST00000422863, ENST00000460633, ENST00000482745, ENST00000496318
Description: Major histocompatibility complex, class II, DQ alpha 1
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
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Gene Symbol: HLA-DPB2 (Human)Other Aliases: HLA-DPB2
Refseq IDs: ENST00000435074, ENST00000435499, ENST00000470997, NR_001435
Description: Major histocompatibility complex, class II, DP beta 2 (pseudogene)
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Gene Symbol: HLA-DPB1 (Human)Other Aliases: DPB1, HLA-DP, HLA-DP1B, HLA-DPB
Refseq IDs: NM_002121, ENST00000416804, ENST00000418931, ENST00000428835, ENST00000469120, ENST00000471184, ENST00000478189, ENST00000488575, ENST00000498038, ENST00000535465
Description: Major histocompatibility complex, class II, DP beta 1
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
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Gene Symbol: HLA-DPA3 (Human)Other Aliases: HLA-DPA3
Refseq IDs: ENST00000454398
Description: Major histocompatibility complex, class II, DP alpha 3 (pseudogene) [Source:HGNC Symbol;Acc:19393]
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Gene Symbol: HLA-DPA2 (Human)Other Aliases: HLA-DPA2
Refseq IDs: ENST00000433582
Description: Major histocompatibility complex, class II, DP alpha 2 (pseudogene) [Source:HGNC Symbol;Acc:4939]
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Gene Symbol: HLA-DPA1 (Human)Other Aliases: DP(W3), DP(W4), HLA-DP1A, HLADP, HLASB, PLT1
Refseq IDs: NM_033554, NM_001242524, NM_001242525, ENST00000417724, ENST00000419277, ENST00000428995, ENST00000437811, ENST00000453337, ENST00000463066, ENST00000476642, ENST00000479107
Description: Major histocompatibility complex, class II, DP alpha 1
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
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Gene Symbol: HLA-DOB (Human)Other Aliases: DOB
Refseq IDs: NM_002120, ENST00000438763, ENST00000447394, ENST00000475235, ENST00000488325
Description: Major histocompatibility complex, class II, DO beta
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
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Gene Symbol: HLA-DOA (Human)Other Aliases: HLA-DNA, HLA-DZA, HLADZ
Refseq IDs: NM_002119, XM_005249047, XM_005249048, XM_005272804, XM_005272805, XM_005274951, XM_005274952, XM_005275106, XM_005275107, XM_005275243, XM_005275244, XM_005275383, XM_005275384, XM_005275540, XM_005275541, ENST00000229829, ENST00000374813, ENST00000450833, ENST00000467465, ENST00000485901, ENST00000490305, ENST00000495532
Description: Major histocompatibility complex, class II, DO alpha
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
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Gene Symbol: HLA-DMB (Human)Other Aliases: D6S221E, RING7
Refseq IDs: NM_002118, XM_005249045, XM_005249046, XM_005272803, XM_005274851, XM_005274852, XM_005274853, XM_005274948, XM_005274949, XM_005274950, XM_005275103, XM_005275104, XM_005275105, XM_005275241, XM_005275242, XM_005275380, XM_005275381, XM_005275382, XM_005275538, XM_005275539, ENST00000414017, ENST00000416244, ENST00000418107, ENST00000438510, ENST00000477537, ENST00000487996, ENST00000498020
Description: Major histocompatibility complex, class II, DM beta
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
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Gene Symbol: HLA-DMA (Human)Other Aliases: D6S222E, DMA, HLADM, RING6
Refseq IDs: NM_006120, XM_005249044, XM_005272801, XM_005272802, XM_005274849, XM_005274850, XM_005274947, XM_005275101, XM_005275102, XM_005275239, XM_005275240, XM_005275378, XM_005275379, XM_005275536, XM_005275537, ENST00000374843, ENST00000395303, ENST00000395305, ENST00000422832, ENST00000456800, ENST00000464392, ENST00000475627, ENST00000477541, ENST00000480785
Description: Major histocompatibility complex, class II, DM alpha
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
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Gene Symbol: HLA-C (Human)Other Aliases: D6S204, HLA-JY3, HLC-C, PSORS1
Refseq IDs: NM_002117, NM_001243042, ENST00000376228, ENST00000376237, ENST00000383329, ENST00000415537, ENST00000466892, ENST00000470363, ENST00000484378, ENST00000487245, ENST00000495835
Description: Major histocompatibility complex, class I, C
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
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Gene Symbol: HLA-B (Human)Other Aliases: AS, HLAB, SPDA1
Refseq IDs: NM_005514, XM_005249043, XM_005272800, XM_005275100, XM_005275238, XM_005275376, XM_005275377, XM_005275535, XR_246962, ENST00000412585, ENST00000434333, ENST00000463574, ENST00000474381, ENST00000481849, ENST00000497377, ENST00000498007
Description: Major histocompatibility complex, class I, B
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described
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Gene Symbol: HLA-AS1 (Human)Other Aliases: HLA-AS1
Refseq IDs: ENST00000552026
Description: HLA antisense RNA 1 [Source:HGNC Symbol;Acc:42509]
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Gene Symbol: HLA-A (Human)Other Aliases: HLAA
Refseq IDs: NM_002116, NM_001242758, XM_005275329, XM_005275330, XM_005275331, ENST00000376802, ENST00000376806, ENST00000376809, ENST00000396634, ENST00000461903, ENST00000479320, ENST00000495183, ENST00000496081
Description: Major histocompatibility complex, class I, A
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
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Gene Symbol: HFE (Human)Other Aliases: HFE1, HH, HLA-H, MVCD7, TFQTL2
Refseq IDs: NM_000410, NM_139011, NM_139010, NM_139009, NM_139008, NM_139007, NM_139006, NM_139004, NM_139003, XM_005249040, XR_241893, XR_241894, ENST00000309234, ENST00000317896, ENST00000336625, ENST00000349999, ENST00000352392, ENST00000353147, ENST00000357618, ENST00000397022, ENST00000461397, ENST00000470149, ENST00000483782, ENST00000485729, ENST00000486147, ENST00000488199
Description: Hemochromatosis
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least eleven alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
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Gene Symbol: HCP5 (Human)Other Aliases: 6S2650E, D6S2650E, P5-1
Refseq IDs: NR_040662, ENST00000414046, ENST00000460889, ENST00000467369, ENST00000541196
Description: HLA complex P5 (non-protein coding)
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Gene Symbol: HCG9P5 (Human)Other Aliases: HCG9P5
Refseq IDs: ENST00000435408
Description: HLA complex group 9 pseudogene 5 [Source:HGNC Symbol;Acc:30983]
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Gene Symbol: HCG9 (Human)Other Aliases: HCGIX, HCGIX4
Refseq IDs: NR_028032, ENST00000376800, ENST00000463275
Description: HLA complex group 9 (non-protein coding)
This gene lies within the MHC class I region on chromosome 6p21.3. The function of the encoded protein has not been determined.
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Gene Symbol: HCG8 (Human)Other Aliases: HCG8
Refseq IDs: NR_103542
Description: HLA complex group 8
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Gene Symbol: HCG4P8 (Human)Other Aliases: HCG4P8
Refseq IDs: ENST00000443049
Description: HLA complex group 4 pseudogene 8 [Source:HGNC Symbol;Acc:22927]
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Gene Symbol: HCG4P7 (Human)Other Aliases: HCG4P7
Refseq IDs: ENST00000420084
Description: HLA complex group 4 pseudogene 7 [Source:HGNC Symbol;Acc:22926]
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Gene Symbol: HCG4P5 (Human)Other Aliases: HCG4P5
Refseq IDs: ENST00000429656
Description: HLA complex group 4 pseudogene 5 [Source:HGNC Symbol;Acc:22925]
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Gene Symbol: HCG4P3 (Human)Other Aliases: HCG4P3
Refseq IDs: ENST00000458060
Description: HLA complex group 4 pseudogene 3 [Source:HGNC Symbol;Acc:22922]
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Gene Symbol: HCG4P11 (Human)Other Aliases: HCG4P11
Refseq IDs: ENST00000427340
Description: HLA complex group 4 pseudogene 11 [Source:HGNC Symbol;Acc:22930]
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Gene Symbol: HCG4B (Human)Other Aliases: HCG4B
Refseq IDs: ENST00000450128, NR_001317
Description: HLA complex group 4B (non-protein coding)
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Gene Symbol: HCG4 (Human)Other Aliases: HCG4P10, HCGIV-10, HCGIV.9
Refseq IDs: NR_002139, ENST00000320533, ENST00000418983
Description: HLA complex group 4 (non-protein coding)
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Gene Symbol: HCG27 (Human)Other Aliases: bCX101P6.9, bPG299F13.9, bQB115I13.2
Refseq IDs: NR_026791, ENST00000383331, ENST00000414008, ENST00000415276, ENST00000424675
Description: HLA complex group 27
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Gene Symbol: HCG26 (Human)Other Aliases: HCG26
Refseq IDs: NR_002812
Description: HLA complex group 26 (non-protein coding)
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Gene Symbol: HCG25 (Human)Other Aliases: HCG25
Refseq IDs: ENST00000422366, ENST00000427196, ENST00000442228, ENST00000450514, NR_044997
Description: HLA complex group 25 (non-protein coding)
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Gene Symbol: HCG24 (Human)Other Aliases: HCG24
Refseq IDs: ENST00000414398
Description: HLA complex group 24 (non-protein coding) [Source:HGNC Symbol;Acc:23500]
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Gene Symbol: HCG23 (Human)Other Aliases: HCG23
Refseq IDs: ENST00000426643, NR_044996
Description: HLA complex group 23 (non-protein coding)
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Gene Symbol: HCG22 (Human)Other Aliases: PBMUCL2
Refseq IDs: NR_003948, ENST00000426185, ENST00000562344, ENST00000565192, ENST00000566475, ENST00000570223
Description: HLA complex group 22
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Gene Symbol: HCG21 (Human)Other Aliases: HCG21
Refseq IDs: ENST00000419481
Description: HLA complex group 21 (non-protein coding) [Source:HGNC Symbol;Acc:31335]
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Gene Symbol: HCG20 (Human)Other Aliases: HCG20
Refseq IDs: ENST00000422944, ENST00000439406
Description: HLA complex group 20 (non-protein coding) [Source:HGNC Symbol;Acc:31334]
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Gene Symbol: HCG19P (Human)Other Aliases: HCG19P
Refseq IDs: ENST00000448756
Description: HLA complex group 19 pseudogene [Source:HGNC Symbol;Acc:31336]
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Gene Symbol: HCG18 (Human)Other Aliases: HCG18
Refseq IDs: ENST00000412685, ENST00000413358, ENST00000426882, ENST00000438412, ENST00000444126, ENST00000449544, ENST00000454129, ENST00000454269, ENST00000602290, ENST00000602319, ENST00000602498, ENST00000602516, ENST00000602550, ENST00000602591, ENST00000602698, ENST00000602861, NR_024052, NR_024053, NR_102326, NR_102327, XR_241900, XR_241901, XR_241902
Description: HLA complex group 18 (non-protein coding)
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Gene Symbol: HCG17 (Human)Other Aliases: HCG17
Refseq IDs: ENST00000453558, ENST00000455957, NR_052012
Description: HLA complex group 17 (non-protein coding)
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Gene Symbol: HCG16 (Human)Other Aliases: HCG15, HCG16
Refseq IDs: ENST00000438190, XR_241996
Description: HLA complex group 16 (non-protein coding)
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Gene Symbol: HCG16 (Human)Other Aliases: HCG16
Refseq IDs: ENST00000445544
Description: HLA complex group 16 (non-protein coding) [Source:HGNC Symbol;Acc:20424]
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Gene Symbol: HCG14 (Human)Other Aliases: HCG14
Refseq IDs: ENST00000444986, XR_241995
Description: HLA complex group 14 (non-protein coding)
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Gene Symbol: HCG11 (Human)Other Aliases: HCG11
Refseq IDs: ENST00000411553, NR_026790
Description: HLA complex group 11 (non-protein coding)
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Gene Symbol: CCNL2 (Human)Other Aliases: ANIA-6B, CCNM, HCLA-ISO, HLA-ISO, PCEE, SB138
Refseq IDs: NM_030937, NM_001039577, XM_005244803, XM_005244804, XR_241043, XR_241044, ENST00000400809, ENST00000408918, ENST00000408952, ENST00000418865, ENST00000425598, ENST00000463260, ENST00000463895, ENST00000469113, ENST00000471930, ENST00000473872, ENST00000480479, ENST00000480646, ENST00000481223, ENST00000482365, ENST00000482621, ENST00000488340, ENST00000492998, ENST00000496007, ENST00000497013, ENST00000505849
Description: Cyclin L2
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