GEArray® Q Series Human Apoptosis Gene Array: HS-002
 
Description
GEArray® Q series Human Apoptosis Gene Array is designed to profile the expression of 96 key genes involved in apoptosis. The genes are grouped into eleven categories according to their functional and structural features, and include the TNF ligands, TNF receptors, bcl-2, caspases, IAP, TRAF, CARD, death domain family members, death effector domain family members, CIDE domain family members, as well as genes involved in the p53 and ATM pathways. Through a simple side-by-side hybridization, using your experimental RNA samples and the arrays and reagents provided in the kit, you can determine simultaneously the expression profile of these 96 genes involved in apoptosis.

Need more information about GEArray products? please visit Microarray Home or send Email to Technical Support

Useful Links
User Manual Gene Table shRNA Plasmids
Pricing and Ordering PCR Primers
Functional Gene Grouping

TNF Ligand Family: LTA (TNF-b), LTB (LT-b), TNF (TNF-a ), TNFSF4 (OX40 Ligand), TNFSF5 (CD40 Ligand), TNFSF6 (FasL), TNFSF7 (CD27 Ligand), TNFSF8 (CD30 Ligand), TNFSF9 (4-1BB Ligand), TNFSF10 (TRAIL), TNFSF11 (TRANCE), TNFSF12 (Apo3L), TNFSF13 (APRIL), TNFSF14 (HVEM-L)

TNF Receptor Family: LTBR, TNFRSF1A (TNFR1), TNFRSF1B (TNFR2), TNFRSF4 (OX40), TNFRSF5 (CD40), TNFRSF6 (Fas), TNFRSF7 (CD27), TNFRSF8 (CD30), TNFRSF9 (4-1BB), TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1), TNFRSF10D (DcR2), TNFRSF12 (DR3), TNFRSF14 (HVEM)

Bcl-2 Family: BAD, BAK1, BAX, BCL2, BCL2A1 (bfl-1), BCL2L1 (bcl-x), BCL2L11 (bim-like protein), BCL2L2 (bcl-w), BIK, BLK, BNIP3 (nip3), BOK (Mtd), HRK, MCL-1

Caspase Family: CASP1, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CASP10, CASP13, CASP14

IAP Family: BIRC1 (NIAP), BIRC2 (IAP2), BIRC3 (IAP1), BIRC4 (XIAP), BIRC5 (Survivin), BIRC6 (Bruce)

TRAF Family: TANK (I-TRAF), TRAF1, TRAF2, TRAF3 (CRAF1), TRAF4, TRAF5, TRAF6, TRIP

CARD Family: APAF1, ASC, BCL10 (HuE10), NOD1 (CARD4), NOL3 (Nop30), RIPK2 (CARDIAC)

Death Domain Family: CRADD, DAPK2, FADD, MYD88, RIPK1

Death Effector Domain Family: CASP8AP2 (FLASH), CFLAR (CASPER), FADD, LOC51283 (BAR)

CIDE Domain Family: CIDEA, CIDEB, DFFA, DFFB

p53 and ATM Pathway: ATM, CHEK1 (chk1), CHEK2 (chk2, Rad53), GADD45A, MDM2, P63, RPA3, TP53 (p53)

Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Green, DR. (2000) Apoptotic Pathways: Paper Wraps Stone Blunts Scissors. Cell 102 : 1-4.
  2. Salvesen GS, Dixit VM. (1999) Caspase Activation: The Induced-Proximity Model. PNAS 96 : 10964-7.
  3. Nagata S (1999) Fas Ligand-Induced Apoptosis. Annu Rev Genet 33 : 29-55.
  4. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. (1999) Biochemical Pathways Of Caspase Activation During Apoptosis. Annu Rev Cell Dev Biol 15 : 269-90.
  5. Ekert PG, Silke J, Vaux DL (1999) Caspase Inhibitors. Cell Death Differ 6 (11): 1081-6
  6. Lutz RJ (2000) Role Of The BH3 (Bcl-2 Homology 3) Domain In The Regulation Of Apoptosis And Bcl-2-Related Proteins. Biochem Soc Trans 28 (2): 51-6.
  7. Inoue Ji, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T. (2000) Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling. Exp Cell Res 254 (1): 14-24.
  8. Deveraux QL, Stennicke HR, Salvesen GS, Reed JC (1999) Endogenous Inhibitors Of Caspases. J Clin Immunol 19 (6): 388-98.
  9. Orlinick JR, Chao MV. (1998) TNF-Related Ligands And Their Receptors. Cell Signal 10 (8): 543-51.
  10. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME (1998) Apoptosis Signaling By Death Receptors. Eur J Biochem 254 (3): 439-59.
  11. Singh A, Ni J, Aggarwal BB (1998) Death Domain Receptors And Their Role In Cell Demise. J Interferon Cytokine Res 18 (7): 439-50.
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Pricing and Ordering
User Manual
Gene Table
  PCR Primers  
  shRNA Plasmids  
Product Support
How It Works
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