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Oligo GEArray® Human Endothelial Cell Biology Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OHS-015
HybPlate Format Cat. No.: EHS-015

Description

The Oligo GEArray® Human Endothelial Cell Biology Microarray is designed to analyze the expression of 113 genes associated with endothelial cell biology. Endothelial cells play a critical role in the progression of disease processes including inflammation, atherosclerosis, and tumor angiogenesis. This array includes gene involved in permissibility and vessel tone, angiogenesis, endothelial cell activation and endothelial cell injury. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

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shRNA Plasmids

qPCR Gene Assays

Modify This Array

Functional Gene Grouping

Permeability and Vessel Tone:
Angiotensin System: AGTR1, AGTR2, BLR1, MAS1.
NO System: NOS2A, NOS3.
Prostacyclin System: PTGIS, PTGS2.
Endothelin System: EDNRA, EDNRB.
Oxidoreductase Activity: ALOX5, NOS2A, NOS3, PTGIS, PTGS2, SOD1, XDH.
Regulation of Blood Pressure: ACE, AGT, AGTR2, CHGA, EDN1, EDN2, EDN3, EDNRA, NPPB, NPR1, PTGS2.
Regulation of Vascular Permeability: AZU1, NPPB, NPR1.
Vasoconstriction: EDN1, EDN2, EDN3.

Angiogenesis:
Negative Regulation of Angiogenesis: KLK3, NPPB, NPR1, PF4.
Positive Regulation of Angiogenesis: ANGPTL3, RHOB, SPHK1.
Other Genes Involved in Angiogenesis: ANGPT1, ANGPT2, ECGF1, FGF1, FGF2, FLT1, IL8, KDR, PGF, VEGF.

Endothelial Cell Activation:
Adhesion Molecules: ANGPTL3, AZU1, CCL2, CCL5, CDH5, COL18A1, CX3CL1, FN1, ICAM1, ICAM2, ICAM3, IL8, ITGA5, ITGAV, ITGB1, ITGB3, OCLN, PECAM1, RHOB, SELE, SELL, SELPLG, TEK, THBS1, TNF, VCAM1, VWF.
Extracellular Matrix Molecules (ECMs): ACE, ACE2, ADAM17, AGT, ANGPT2, ANGPTL3, AZU1, CCL2, CCL20, CCL5, CHGA, COL18A1, CPB2, CSF2, ECGF1, EDN1, EDN2, EDN3, ENPEP, FGF1, FGF2, FLT1, FN1, IL15, IL1B, IL3, IL6, IL7, IL8, KLK3, MMP1, MMP14, MMP2, MMP9, NPPB, PLAT, PLAU, SERPINE1, TFPI, TFPI2, THBS1, TIMP1, TNFSF6, VWF.
Cytokine Activity: CCL20, CCL5, CSF2, CSF3, CX3CL1, F3, IFNB1, IL11, IL14, IL15, IL1B, IL3, IL6, IL7, IL8, PF4, TNF, TNFRSF11B, TNFSF10, TNFSF6.
Thrombin Activity: ANXA5, PLAT, PLAU, PLG, THBD.
Vascular Endothelial Growth Factor (VEGF) Receptor Activity: FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB, VEGF.
Other Genes Involved in Cell Growth: BAX, BCL2, COL18A1, CSF2, CSF3, ECGF1, EDN1, EDN2, EDNRA, ENPEP, FGF1, FGF2, IFNB1, IL11, IL14, IL15, IL1B, IL3, IL6, IL7, IL8, MAS1, NOS2A, NPPB, PGF, PLG, RHOB, SPHK1, TIMP1, VWF.

Endothelial Cell Injury:
Response to Stress: ALOX5, AZU1, BCL2, CCL2, CCL20, CCL5, CSF2, CSF3, CX3CL1, FN1, IFNB1, IL1B,
IL6, IL7, IL8, ITGB1, NOS2A, PF4, PLA2G4C, PTGS2, SELE, SELPLG, SOD1, TNF, VEGF, VWF.
Anti-Apoptosis: AZU1, BAX, BCL2, BCL2A1, BCL2L1, CCL2, CFLAR, SPHK1, TNF, TNFAIP3, TNFRSF6.
Caspase Activation: CASP1, CASP10, CASP3, CASP6, CFLAR, IFNB1.
Induction of Apoptosis: BAX, CASP10, CASP3, CASP6, CFLAR, CRADD, TNFRSF6, TNFSF10, TNFSF6.
Other Apoptosis Genes: AGTR2, IL1B, RHOB, RIPK1, TNFRSF10C, TNFRSF10D, TNFRSF11B, VEGF.

Other factors involved in Inflammatory Response: ABCF1, BCL6, C3, C4A, CEBPB, CRP, EDG3, ICEBERG, LTB4R.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

Geimonen E, Neff S, Raymond T, Kocer SS, Gavrilovskaya IN, Mackow ER. Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses. Proc Natl Acad Sci U S A. 2002 Oct 15; 99 (21): 13837-42.
Maragoudakis ME, Tsopanoglou NE, Andriopoulou P. Mechanism of thrombin-induced angiogenesis. Biochem Soc Trans. 2002 Apr; 30 (2): 173-177.
Choy JC, Granville DJ, Hunt DW, McManus BM. Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol. 2001 Sep; 33 (9): 1673-90.
Kim J, Wu H, Hawthorne L, Rafii S, Laurence J. Endothelial cell apoptotic genes associated with the pathogenesis of thrombotic microangiopathies: an application of oligonucleotide genechip technology. Microvasc Res. 2001 Sep; 62 (2): 83-93.
Biedermann BC. Vascular endothelium: checkpoint for inflammation and immunity. News Physiol Sci. 2001 Apr; 16: 84-8
Malyszko J, Malyszko JS, Mysliwiec M. Markers of endothelial cell injury and thrombin activatable fibrinolysis inhibitor in nephrotic syndrome. Blood Coagul Fibrinolysis. 2002 Oct; 13 (7): 615-21.
Takehana K, Konishi A, Oonuki A, Noguchi M, Fujita K, Iino Y, Kobayashi T. APC0576, a novel inhibitor of NF-kappaB-dependent gene activation, prevents pro-inflammatory cytokine-induced chemokine production in human endothelial cells. Biochem Biophys Res Commun. 2002 May 10; 293 (3): 945-52.
Hunt BJ. The endothelium in atherogenesis. Lupus. 2000; 9 (3): 189-93.
Pearson JD. Normal endothelial cell function. Lupus. 2000; 9 (3): 183-8.
Toborek M, Kaiser S. Endothelial cell functions. Relationship to atherogenesis. Basic Res Cardiol. 1999 Oct; 94 (5): 295-314.