Human NFkB Signaling Pathway

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Oligo GEArray® Human NFkB Signaling Pathway Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OHS-025
HybPlate Format Cat. No.: EHS-025

Description

The Oligo GEArray® Human NFκB Signaling Pathway Microarray profiles the expression of 113 genes related to NFκB-mediated signal transduction. The array includes genes that encode members of the Rel, NFκB, and IκB families, NFκB-responsive genes, extracellular ligands and receptors that activate the pathway, and kinases and transcription factors that propagate the signal. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

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shRNA Plasmids

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Functional Gene Grouping

Activation of the NFκB Pathway:
Ligands and Receptors: CARD10, IL1B, IL8, MYD88, TLR1, TLR2, TLR3, TLR4, TLR6, TLR8, TNF (TNF-α), TNFRSF10A, TNFRSF10B
Membrane Molecules: CARD11, CARD14, IRAK1, IRAK2.
Kinases: CHUK (IKK-&aplha;), IKBKB (IKK-β), IKBKG (IKK-γ), IRAK1, IRAK2, MAP2K3, MAP2K4 (mkk4 / JNKK1), MAP2K6, MAP3K14 (NIK), MAP3K7 (TAK1), MAPK14 (p38 MAPK).
IκB Kinase/NFκB Cascade: EDARADD, IKBKG, IRAK2, STAT1, TLR8.
Cytoplasmic Sequestering / Release of NFκB: BCL3, IL10, NALP12, NFKBIA (IκBα / mad3), TNFRSF7, TNFSF14.
Transcription Factors: IKBKB, IKBKG, IRAK1, NFKB1, NFKBIA, RELA, STAT1, TNF (TNF-α).
Inflammatory Response: IL1B, IL8, IRAK2, MYD88, NFKB1, TLR1, TLR2, TLR3, TLR4, TLR6, TLR8, TNF (TNF-α).

Positive Regulation of IκB Kinase and the NFκB Signaling Cascade:
Ligands and Receptors: F2R, GPR89, HTR2B, LTBR, SLC20A1, TICAM2, TNFRSF1A, TNFRSF5, TNFSF10, TNFSF6, TRIF.
Membrane Molecules: EDG2, GJA1, HMOX1, RHOA, VAPA.
Kinases: IKBKE (IKK-i), MAP3K3, MAP3K7IP2, PLK2, RIPK1 (RIP), RIPK2, TBK1.
Other Genes Involved in Positive Regulation of IκB Kinase and the NFκB Signaling Cascade: APOL3, BCL10, BIRC2, CARD4, CASP1, CASP8, CFLAR, CTL2, CXXC5, ECM1, FADD, HNLF, LITAF, MALT1, PPM1A, PPP5C, REL, RFP2, RHOC, TRADD, TRAF5, TRAF6.

NFκB Responsive Genes:
Acute Phase Response Proteins: AGT (angiotensinogen), BF, C3 (C3 complement).
Adhesion Molecules: ICAM1.
Extracellular Molecules: BF, CSF2 (GM-CSF), CSF3 (G-CSF), IFNA1, IFNB1, IFNG, IL6.
Ligands and Receptors: AGT (angiotensinogen), C3 (C3 complement), CCL2 (MCP-1), ICAM1, LTA (TNF-β).
Cytokines: CCL2 (MCP-1), CSF2 (GM-CSF), CSF3 (G-CSF), IFNA1, IFNB1, IFNG, IL6, IL8, LTA (TNF-β), TNF (TNF-α)
Inflammatory Response: C3 (C3 complement), CCL2 (MCP-1).

Other Factors Involved in the NFκB Pathway:
Extracellular Molecules: IL1A.
Ligands and Receptors: IL1R1, MAP3K7IP1 (TAB1), RAF1, TLR10, TLR7, TLR9.
Kinases: AKT1, MAP3K1 (MEKK1), MAPK3 (ERK1), MAPK8 (JNK1), RAF1.
Transcription Factors: ATF1, ATF2 (CREB-2), EGR1, ELK1, FOS, JUN, NFKB2, RELB, TNFAIP3 (A20).
Inflammatory Response: FOS, IL1A, IL1R1, TLR10, TLR7, TLR9

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

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Shimizu, K., Nagamachi, Y., Tani, M., Kimura, K., Shiroishi, T. Wakana, S., and Yokota, J. (2000) Molecular Cloning of a Novel NF2/ERM/4.1 Superfamily Gene, Ehm2, That Is Expressed in High-Metastatic K1735 Murine Melanoma Cells. Genomics 65: 113-20.
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Engers, R., and Gabbert, H.E. (2000) Mechanisms of Tumor Metastasis: Cell Biological Aspects and Clinical Implications. J Cancer Res Clin Oncol 126: 682-92.
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Saaristo, A., Karpanen, T., and Alitalo, K. (2000) Mechanisms of Angiogenesis and Their Use in the Inhibition of Tumor Growth and Metastasis. Oncogene 19: 6122-9. Yu, D., and Hung, M.C. (2000) Overexpression of ErbB2 in Cancer and ErbB2-Targeting Strategies. Oncogene 19: 6115-21.
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