Human TGFβ BMP Signaling Pathway

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Oligo GEArray® Human TGFβ BMP Signaling Pathway Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OHS-035
HybPlate Format Cat. No.: EHS-035

Description

The Oligo GEArray® Human TGFβ BMP Signaling Pathway Microarray profiles the expression of 113 genes related to TGFβ BMP-mediated signal transduction. The array includes members of the TGFβ superfamily of cytokines and their receptors. SMAD and SMAD target genes are included. Related genes including adhesion and extracellular molecules and transcription factors are included. Some of the genes involved in downstream cellular and developmental processes are also represented. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

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Functional Gene Grouping

TGF-β Superfamily Cytokines:
TGF-β: TGFB1, TGFB2, TGFB3.
BMP: BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8B, BMP10, BMP15.GDF: AMH, GDF1, GDF2 (BMP9), GDF3 (Vgr-2), GDF5 (CDMP-1), GDF6, GDF7, GDF8, GDF9, GDF10, GDF11 (BMP11), GDF15, IGF1, IGFBP3, IL6, INHA (inhibin a), INHBA (inhibin BA), IVL (involucrin), LEFTY1, LEFTY2, LTBP1, LTBP2, LTBP4, NODAL, PDGFB, TDGF1.
Activin: INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), INHBC (inhibin BC), INHBE, LEFTY1, LEFTY2, NODAL.

Receptors: ACVR1 (ALK2), ACVR1B (ALK4), ACVR1C, ACVR2, ACVR2B, ACVRL1 (ALK1), AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, ITGB5 (integrin B5), ITGB7 (integrin B7), LTBP1, MAP3K7IP1, NR0B1, STAT1, TGFB1I1, TGFBR1 (ALK5), TGFBR2, TGFBR3, TGFBRAP1.

SMAD: SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SMAD6 (MADH6), SMAD7 (MADH7), SMAD9 (MADH9).

SMAD Target Genes:
TGF-β Activin-responsive: CDC25A, CDKN1A (p21WAF1 / p21CIP1), CDKN2B (p15LNK2B), COL1A1, COL1A2, COL3A1, FOS, GSC (goosecoid), IGF1, IGFBP3, IL6, ITGB5 (integrin B5), ITGB7 (integrin B7), IVL (involucrin), JUN, JUNB, MYC, PDGFB, SERPINE 1 (PAI-1), TGFB1I1, TGFB1I4, TGFBI, TGIF, TIMP1.
BMP-Responsive: BGLAP (osteocalcin), DLX2, ID1, ID2, ID3, ID4, JUNB, SMAD6 (MADH6), SOX4, STAT1, TCF8.
Molecules Regulating Signaling of the TGF-β Superfamily: BAMBI, BMPER, CDKN2B (p15LNK2B), CER1 (cerberus), CHRD (chordin), CST3, ENG (Evi-1), EVI1, FKBP1B, FST (follistatin), GREM1, HIPK2, MAP3K7, NBL1 (DAN), NOG, PLAU (uPA), RUNX1 (AML1), RUNX2, SMURF1, SMURF2, TDGF1.

Adhesion and Extracellular Molecules:
Cell Adhesion Molecules: BGLAP (osteocalcin), ENG (Evi-1), ITGB5 (integrin B5), ITGB7 (integrin B7), TGFB1I1, TGFBI.
Extracellular Matrix Structural Constituents: BGLAP (osteocalcin), COL1A1, COL1A2, COL3A1, IVL (involucrin), LTBP1, LTBP2, LTBP4, TGFBI, TIMP1.
Other Extracellular Molecules: AMH, BMP1, BMP10, BMP15, BMP2, FST (follistatin), GDF1, GDF10, GDF15, GDF2 (BMP9), GDF3 (Vgr-2), GDF9, GREM1, IGF1, IGFBP3, IL6, INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), INHBC (inhibin BC), PDGFB, PLAU (uPA), SERPINE1.

Transcription Factors and Regulators: DLX2, EVI1, FOS, GSC (goosecoid), HIPK2, ID1, ID3, ID4, JUN, JUNB, MYC, NR0B1, RUNX1 (AML1), RUNX2, SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SMAD6 (MADH6), SMAD7 (MADH7), SMAD9 (MADH9), SMURF2, SOX4, STAT1, TCF8 (AREB6), TGFB1I1, TGFB1I4, TGIF.

Genes Involved in Cellular and Developmental Processes:
Apoptosis: CDKN1A (p21WAF1 / p21CIP1), HIPK2, IGFBP3, INHA (inhibin a), INHBA (inhibin BA), STAT1, TDGF1, TGFB1.
Embryonic Development: BMP10, BMP4, GDF11 (BMP11), INHBA (inhibin BA), SMAD3, SMURF1, TDGF1.
Muscle Development: GDF8, GDF9, IGF1, SMAD3.
Neurogenesis: DLX2, GDF11 (BMP11), GREM1, INHA (inhibin a), INHBA (inhibin BA), NOG.
Reproduction: AMH, AMHR2, BMP15, FST (follistatin), GDF9, INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), INHBC (inhibin BC), LEFTY2, NR0B1, TDGF1.
Skeletal Development: BGLAP (osteocalcin), BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8B, BMPR2, CHRD (chordin), COL1A1, COL1A2, GDF10, GDF11 (BMP11), IGF1, INHA (inhibin a), INHBA (inhibin BA), NOG, RUNX2.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

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Arbour, N., D. Naniche, et al. (2002). "c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity." J Exp Med 195 (7): 801-10.
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Das, J., C. H. Chen, et al. (2001). "A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation." Nat Immunol 2 (1): 45-50.
de Waal Malefyt, R., J. S. Abrams, et al. (1995). "Differential regulation of IL-13 and IL-4 production by human CD8+ and CD4+ Th0, Th1 and Th2 T cell clones and EBV-transformed B cells." Int. Immunol. 7 (9): 1405-16.
Egwuagu, C. E., C. R. Yu, et al. (2002). "Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance." J Immunol 168 (7): 3181-7.
Karpus, W. J. and K. J. Kennedy (1997). "MIP-1alpha and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation." J Leukoc Biol 62 (5): 681-7.
Weiner HL (2001). ôInduction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells.ö Immunol Rev 182: 207-14..