JAK & STAT Proteins:
Janus Kinase Activity: JAK1, JAK2, JAK3, TYK2. STAT Family: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. Receptors that Bind and Activate JAK Proteins: CSF1R, CSF2RB, EGFR, EPOR, F2R, GHR, IFNAR1, IFNAR2, IFNGR1, IFNGR2, IL10RA, IL10RB, IL20RA, IL22RA1, IL2RA, IL2RG, IL31RA, IL4R, IL6ST, INSR, MPL, PDGFRA, SH2B. SH3/SH2 Adaptor Protein Activity: APS, CRK, CRKL, SCAP2, SIT, SLA2, SRC, STAM. STAT Protein Nuclear Translocation: F2, F2R, STAT1. Tyrosine Phosphorylation of STAT Protein: F2, F2R, IL20, IL31RA, PPP2R1A, PPP2R1B, PRLR, STAT1. Transcription Factors or Regulators that Interact with STAT Proteins:
Positive Regulation of Transcription: HMGA1, IL31RA, SMAD3. Negative Regulation of Transcription: PIAS4, SLA2, SMAD3, SPI1, STAT3. RNA Polymerase II Transcription Factor Activity: JUNB, MAF, MHC2TA, SP1, USF1. Transcription Coactivator Activity: CREBBP, IL31RA, JUNB, MHC2TA, NCOA1, YY1. Transcription Corepressor Activity: JUNB, PIAS1, PIAS3, YY1. Transcriptional Activator Activity: SMAD1, SMAD5, SP1. Other Transcription Factors and Regulators: CEBPB, CRK, GATA3, IRF1, ISGF3G, JUN, MCM5, MYC, NFKB1, NMI, NR3C1, PPP2R1A, PPP2R1B, SMAD2, SMAD4, SMAD6, SMAD7, SMAD9. Genes Induced by STAT Proteins:
Stat1: CXCL9, INDO, IRF1, JUNB, MHC2TA, NOS2A. Stat3: A2M, BCL2L1, CDKN1A, CRP, IRF1, MMP3, MYC, SOCS1, TNFRSF6. Stat4: FCER2, FCGR1A, IFNG, IRF1, MYC. Stat5: CCND1, CDKN1A, CSN2, IL2RA, IRF1, OSM, PIM1. Stat6: FCER1A, GATA3, IGHG3, IL4, IL4R, MAF. Stat1 / Stat1 / p48: GBP1. Stat1 / Stat2 / p48: G1P2, G1P3, INDO, OAS1. Negative Regulators of the JAK / STAT pathway: PIAS1, PIAS2, PIAS3, PIAS4, PTPN1, PTPNS1, PTPRC, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7. Apoptosis: BCL2L1, CDKN1A, F2, F2R, IL2RA, IL31RA, NFKB1, PPP2R1A, PPP2R1B, PRLR, STAT1, TNFRSF6. Cell Differentiation: IL20, IL31RA, IL4, NOS2A, PPP2R1A, PPP2R1B, SOCS2, SOCS5. Cell Growth and/or Maintenance:
Cell Cycle: CCND1, CDKN1A, EGFR, F2, F2R, IL2RA, IRF1, JAK2, MCM5, MYC, PPP2R1A, PPP2R1B, STAT1. Cell Growth: A2M, EGFR, GHR, IFNG, IL4, INSR, OSM, PPP2R1A, PPP2R1B, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6. Cell Proliferation: CSF1R, IL2RG, IL31RA, IL4, MPL, OSM, PDGFRA, SMAD3. Immune Response:
Acute-Phase Response: CEBPB, CRP, F2, STAT3. Antigen Processing: FCER1A, FCER2, FCGR1A, IGHG3, PPP2R1A, PPP2R1B. Humoral Immune Response: APS, CSF1R, CSF2RB, IL4, NFKB1, YY1. Inflammatory Response: CEBPB, CRP, CXCL9, IL10RB, IL20, NFKB1, NMI, NOS2A, NR3C1. Lymphocyte Activation: IL31RA, IL4, PRLR, SIT, SLA2. Other Genes Involved in the Immune Response: CXCL9, G1P2, G1P3, GBP1, IFNG, IL2RA, IL2RG, IL4, IL4R, IL6ST, NDO, IRF1, ISGF3G, OAS1, OSM, STAT5A, TNFRSF6, STUB1. |
