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Oligo GEArray® Human T-cell and B-cell Activation Microarray

Oligo GEArrays - Discontinued Product Announcement - Effective January 1, 2010

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OHS-053
HybPlate Format Cat. No.: EHS-053

Description
The Oligo GEArray® Human T-cell and B-cell Activation Microarray contains 113 genes representing T-cell and B-cell activation, a key part of adaptive immunity. The activation of resting lymphocytes initiates a complex, well coordinated series of events mediating adaptive immunity (1). On one extreme, over-activation of this fine-tuned network can cause a variety of autoimmune diseases such as systemic sclerosis (2), systemic lupus erythematosus (3), and autoimmune hepatitis (4). On the other extreme, the inability to activate T-cells and B-cells against cancerous cells is attributed to the etiology of many different types of cancers. Immunotherapy, guided intervention of this network, may provide treatments for many diseases related to adaptive immunity (5-7). This array provides you with a means of comparing expression of genes related to T-cell and B-cell activation among your experimental samples.

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Useful Links
Pricing and Ordering Gene Table GEArray Service
User Manual White Paper GEArray ThermoShaker
Related Products for the Genes on This Array
shRNA Plasmids qPCR Gene Assays Modify This Array
Functional Gene Grouping

B-cell activation:

Antigen dependent B-cell activation: CD28, CD4, CD80, HLA-DRA, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6.

Other genes involved in B-cell activation: BLR1, HDAC4, HDAC5, HDAC7A, HDAC9, ICOSL, IGBP1, MS4A1, RGS1, SLA2.

B-cell proliferation: CD81, IFNB1, IL10, TNFRSF5, TNFRSF7, TNFSF5.

B-cell differentiation: AICDA, BLNK, GALNAC4S-6ST, HDAC4, HDAC5, HDAC7A, HDAC9, IL10, IL11, IL4, INHA, INHBA, KLF6, TNFRSF7.

T-cell activation:

Regulators of T-cell activation: CD2, CD3D, CD3E, CD3G, CD4, CD7, CD80, CD86, CD8A, CD8B1, CLECSF12, ICOSL, IRF4, KIF13B, NCK1, NCK2, PRLR, SIT, SLA2, TNFSF14.

T-cell proliferation: CD28, CD3E, GLMN, ICOSL, IL10, IL12B, IL18, IL27, NCK1, NCK2, SFTPD, SPP1, TNFSF14.

T-cell differentiation: CD1D, CD2, CD4, CD80, CD86, IL12B, IL2, IL27, IRF4, JAG2, NOS2A, RHOH, SOCS5, TNFRSF7, WWP1.

Regulators of Th1 and Th2 development: ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA2, IFNB1, IFNG, IL10, IL12A, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5.

Genes involved in Th1/Th2 differentiation: CD28, CD86, HLA-DRA, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, PVRL1, TNFRSF5, TNFSF5.

Genes involved in T-cell polarization: CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TNFSF5.

Other genes related to immune cell activation:

Macrophage activation: C1QR1, IL31RA, INHA, INHBA, TLR1, TLR4, TLR6.

Neutrophil activation: APOA2, IL8, PREX1, PRG3.

Natural killer cell activation: CD2, IFNB1, IFNK, IL12B, IL2, IL21R, KIR3DL1, ULBP1, ULBP2, ULBP3.

Others: AZU1, CX3CL1, ITIH1, TOLLIP, TXNDC, ZNF3.

 

Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Tseng, S.-Y. and Dustin, M.L. (2002) Current Opinion in Cell Biology, 14, 575-580.
  2. Tedder, T.F., Poe, J.C., Fujimoto, M., Haas, K.M. and Sato, S. (2005) Curr Dir Autoimmun, 8, 55-90.
  3. Criscione, L.G. and Pisetsky, D.S. (2003) Curr Rheumatol Rep, 5, 264-269.
  4. Jaeckel, E. (2002) Semin Liver Dis, 22, 325-338.
  5. Ragde, H., Cavanagh, W.A. and Tjoa, B.A. (2004) J Urol, 172, 2532-2538.
  6. Wang, E., Panelli, M.C. and Marincola, F.M. (2005) Springer Semin Immunopathol.
  7. Poindexter, N.J., Sahin, A., Hunt, K.K. and Grimm, E.A. (2004) Breast Cancer Res, 6, R408-415.