Genes Involved in Beta-amyloid Generation, Oligomerization, Clearance, and Degradation:
Secretases: ADAM10, ADAM17, ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2.
Other Peptidases Involved in Beta-amyloid Degradation: ECE2, IDE, MME, PLAT, PLAU, PLG.
Beta-amyloid clearance through endocytosis: APLP1, APP, LRP1, LRP10, LRP3, LRP4, LRP5, LRP6, LRP8.
Other genes involved in beta-amyloid metabolism: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1. Genes Involved in Microtubule/Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI, SGCA. Genes Involved in Synaptic Formation:
Synaptic transmission: APBA1, APOE, CHAT, NPY, PDE7B.
Other synaptic functions: ACHE, APBA1, APBB1, APBB2, APOE, BDNF, SYP. Genes Involved in Cholesterol Metabolism: ABCA1, APOA1, APOE, DHCR24, LRP8, SYP. Genes Involved in Lipid and Lipoprotein Metabolism: AGPS, APOA1, APOE, CLU, HADH2, INS, LPL, LRP1, LRP5, LRP8, SNCB. Hormone and Hormone Processing Genes: BACE2, ECE2, GAL, INS, NPY, SST. Genes Involved in Apoptosis:
Induction of Apoptosis: APOE, CASP3, CASP4, ERN1, PRKCA, PRKCE.
Anti-apoptosis: IL1A, MPO, PRKCZ, PSEN1, SNCA.
Other Genes Involved in Apoptosis and cell death: APLP1, APP, APPBP1, CLU, EP300, ERN2, MAPT, PSEN2, VSNL1. Cell Cycle Regulators:
Cell Cycle Arrest: APBB1, APBB2, ERN1.
Other Cell Cycle Genes: APBB1, APBB2, APPBP1, CDC2, CDK5, CDKL1, EP300, IL1A, PRKCA. Protein Kinases: CDC2, CDK5, CDKL1, ERN1, ERN2, GSK3A, GSK3B, INSR, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ. Cell Signaling Molecules:
Wnt Receptor Signaling: GSK3B, LRP5, LRP6.
Notch Signaling: ADAM10, APH1A, NCSTN, PSEN1, PSEN2.
G-protein Coupled Receptor Protein Signaling: APLP2, ECE2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG10, GNG11, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNG8, GNGT1, GNGT2.
Intracellular Signaling: APBA3, APBB2, APBB3, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2.
Other Signaling Molecules: APPBP1, GAL, GAP43, GNB2, IDE, IL1A, INSR, NPY, PLAU. Transcription Regulators: APBB1, APBB2, EGR3, EP300, ERN1, ERN2, FALZ, PHF1, TFAP4. Other Genes Involved in Alzheimer's Disease:
Oxidoreductases and Oxidative Stress: DHCR24, HADH2, MPO, SCARA3, UQCRC1, UQCRC2.
Proteases: ACE, CTSC, CTSD, CTSG, CTSL, SERPINA13, UQCRC2.
Protease Inhibitors: APLP2, APP, SERPINA13, SERPINA3, SPINT2. |
