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Oligo GEArray® Human Notch Signaling Pathway Microarray

Oligo GEArrays - Discontinued Product Announcement - Effective January 1, 2010

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OHS-059
HybPlate Format Cat. No.: EHS-059

Description
The Oligo GEArray® Human Notch Signaling Pathway Microarray is designed for profiling expression of 113 genes involved in Notch signaling. This array contains the Notch pathway∆s binding and receptor processing genes. The putative Notch target genes are also represented. These include genes related to apoptosis, the cell cycle, neurogenesis, and the regulation of transcription as well as genes involved in cell regulation, proliferation, and differentiation. Genes from other signaling pathways that cross-talk with the Notch Signaling Pathway are represented including members of the Sonic Hedgehog and Wnt Receptor Signaling Pathways. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

Need more information about GEArray products? please visit Microarray Home or send Email to Technical Support

Useful Links
Pricing and Ordering Gene Table GEArray Service
User Manual White Paper GEArray ThermoShaker
Related Products for the Genes on This Array
shRNA Plasmids qPCR Gene Assays Modify This Array
Functional Gene Grouping

Notch Signaling Pathway:
Notch Binding: DLL1 (DELTA1), DLL3, DLL4, DTX1, JAG1, JAG2.
Notch Receptor Processing: ADAM10, APH-1A, NCSTN, PEN2, PSEN1, PSEN2.

Notch Signaling Pathway Target Genes:
Apoptosis Genes: CDKN1A, CFLAR (CASH), IL2RA, NFKB1.
Cell Cycle Regulators: CCND1 (Cyclin D1), CDKN1A (P21), CDKN1B (P27), IL2RA.
Cell Proliferation: CDKN1A (P21), CDKN1B (P27), ERBB2, FOSL1, IL2RA.Genes Regulating Cell Differentiation: DTX1, HES6, PPARG.
Neurogenesis: HES1, HEY1, HEY2.
Regulation of Transcription: DTX1, FOS, FOSL1, HES1, HES6, HEY1, HEY2, NFKB1, NFKB2, NR4A2, PPARG, STAT6.
Other Target Genes with Unspecified Functions: CD44, CHUK, HES5, IFNG, IL17B, IVL, KRT1, KRT10, KRT14, KRT5, LOR, MAP2K7, MGC61598, PDPK1, PTCRA.

Other Genes Involved in the Notch Signaling Pathway:
Apoptosis Genes: AXIN1, EP300, HDAC1, NOTCH2, PSEN1, PSEN2.
Cell Cycle Regulators: AXIN1, CCNE1, CDC16, EP300, FIGF, JAG2, NOTCH2, PCAF, PTCH.
Cell Proliferation: CDC16, FIGF, FZD3, JAG1, JAG2, LRP5, NOTCH2, PCAF, PTCH, SIL.
Genes Regulating Cell Differentiation: DLL1, DLL3, DLL4, JAG1, JAG2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PAX5, SHH.Neurogenesis: DLL1, DLL3, EP300, FZD9, HEYL, JAG1, NEURL, NOTCH2, NUMBL, PAX5, RFNG, ZIC2 (HPE5).
Regulation of Transcription: AES, CBL, CIR, CTNNB1, EP300, GLI1, GLI2, GLI3, HDAC1, HEYL, HOXB4, HR, MYCL1, NCOR2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PAX5, PCAF, POFUT1, RBPSUH, RUNX1, SKIIP, SPEN, SUFU, TEAD1, TLE1. ADAM17, GBP2, LFNG, LMO2, MAML1, MAML2, MAP1B, MAPKAPK3, MECT1, MFNG, MMP7, NOTCH2NL, NUMB, SEL1L, SH2D1A, SUPT6H.

Other Signaling Pathways that Crosstalk with the Notch Signaling Pathway:
Sonic Hedgehog (Shh) Pathway: GLI1, GLI2, GLI3, GSK3B, PTCH, SHH, SMO, SUFU.
Wnt Receptor Signaling Pathway: AES, AXIN1, CTNNB1, FZD1, FZD10, FZD2, FZD3, FZD4, FZD6, FZD7, FZD8, FZD9, GSK3B, LRP5, TLE1, WISP1, WNT11.

Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Radtke F, Wilson A, Mancini SJ, MacDonald HR. Notch regulation of lymphocyte development and function. Nat Immunol. 2004 Mar; 5 (3): 247-53.
  2. Zuniga-Pflucker JC. T-cell development made simple. Nat Rev Immunol. 2004 Jan; 4 (1): 67-72.
  3. Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer. 2003 Oct; 3 (10): 756-67.
  4. Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene. 2003 Sep 29; 22 (42): 6598-608.
  5. Hoyne GF. Notch signaling in the immune system. J Leukoc Biol. 2003 Dec; 74 (6): 971-81.
  6. Maillard I, Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell. 2003 Mar; 3 (3): 203-5.
  7. Gridley T. Notch signaling and inherited disease syndromes. Hum Mol Genet. 2003 Apr 1; 12 Spec No 1: R9-13.
  8. Baron M. An overview of the Notch signalling pathway. Semin Cell Dev Biol. 2003 Apr; 14 (2): 113-9.
  9. Ohishi K, Katayama N, Shiku H, Varnum-Finney B, Bernstein ID. Notch signalling in hematopoiesis. Semin Cell Dev Biol. 2003 Apr; 14 (2): 143-50.
  10. Maillard I, Adler SH, Pear WS. Notch and the immune system. Immunity. 2003 Dec; 19 (6): 781-91.
  11. Guidos CJ. Notch signaling in lymphocyte development. Semin Immunol. 2002 Dec; 14 (6): 395-404.