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Oligo GEArray® Human Toxicology & Drug Resistance Microarray

Oligo GEArrays - Discontinued Product Announcement - Effective January 1, 2010

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OHS-401
HybPlate Format Cat. No.: EHS-401

Description
The Oligo GEArray® Human Toxicology & Drug Resistance Microarray profiles the expression of 263 genes related to the metabolic processes of cell stress, cell toxicity, drug resistance, and drug metabolism. Genes critical in drug metabolism and resistance such as those encoding enzymes important for drug transport and phase I metabolism (specifically P450-mediated oxidation) are included. Various covalent modification enzymes important for phase II metabolism are also represented. This array includes genes whose expression level is indicative of stress and toxicity as well as those genes representative of pathways activated by prolonged stress. Among these are genes directly up-regulated by oxidative or metabolic stress and genes involved in cell death by apoptosis or necrosis, growth arrest & senescence, and proliferation & carcinogenesis. Genes involved in cellular stress response are also represented, including those encoding DNA repair enzymes, cell cycle regulators, growth factor and hormone receptors, transcription factors, and molecular chaperones. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links
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Related Products for the Genes on This Array
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Functional Gene Grouping

Apoptosis:
Induction of Apoptosis: BAX, CASP10, CDKN1A, IL18, LTA, TNFSF10, TNFSF6, TP53, TRADD.
Anti-apoptosis: AKT1, BAG1, BCL2, BCL2L1, BCL2L2, IGF1R, IL1A, NFKB1, TNF.
Other Genes Involved in Apoptosis: AHR, BRCA1, CASP1, CASP8, CLU, DNAJA3, E2F1, GADD45A, GADD45B, IL1B, NFKBIA, TNFRSF1A.

Cell Cycle:
Cell Cycle Arrest and Checkpoint: BRCA1, CDKN1A, CDKN1B, CDKN2A, CDKN2D, DDIT3, GADD45A, MYC, RB1, TP53.
Negative Regulation of the Cell Cycle: APC, ATM, BAX, BRCA1, CDKN2A, CDKN2D, MLH1, MSH2, RB1, TP53.
Other Genes Involved in the Cell Cycle: ABL1, AHR, BCL2, BRCA2, CCNC, CCND1, CCNE1, CCNG1, CCT2, CCT4, CCT7, CDK2, CDK4, CHEK2, DNAJA2, E2F1, FGF2, IGF1R, IL1A, IL1B, PCNA, RB1.,/p>

Cell Growth, Proliferation and Differentiation:
Chemokines and Cytokines: CCL21, CCL3, CCL4, CSF2, CXCL10, GDF15, IL18, IL1A, IL1B, IL6, LTA, MIF, TNF, TNFSF10, TNFSF6.
Growth Factors and Receptors: EGFR, ERBB2, ERBB3, ERBB4, FGF2, IGF1R, IGF2R, MET.
Negative Regulators of Cell Growth and Proliferation: BCL2, CDKN1A, CDKN1B, CDKN2A, CDKN2D, ESR2, IGFBP6, IL1A, IL1B, IL6, MDM2, MT3.
Positive Regulators of Cell Growth and Proliferation: CDK2, CXCL10, DNAJA2, FGF2, IGF1R, IL18, IL6, NOS2A, TNFRSF11A.
Other Genes Regulating Cell Growth and Proliferation: ABL1, AR, BCR, BRCA1, CCND1, CDK4, DDIT3, E2F1, ESR1, FOS, IGFBP6, MYC, NFKB2, PCNA, PRDX1, RARA, RARB, TOP1.

Transporters: ABCB1, ABCB4, ABCC1, ABCC2, ABCC3, ABCC5, ABCC6, ABCG2, AP1S1, AR, CRABP1, IGF2R, RAD50, TPMT.

Response to Stress:
Drug Response: ABCB1, ABCB4, ABCC1, ABCC6, ABCG2, CTPS, MVP, NAT8.
Response to DNA Damage Stimulus: ATM, BRCA1, CHEK2, DDIT3, GADD45A, RAD23A, XRCC2.
Response to Oxidative Stress: CAT, GPX1, GPX2, NUDT1, PRDX2, SOD1, SOD2.
Response to Other Stresses: AHR, AKT1, CCL4, CES1, DNAJB4, DNAJB5, EPHX1, EPHX2, ERCC1, GADD45B, GSR, GSTA3, GSTA4, GSTT1, HIF1A, HSPB2, HYOU1, MT1X, MT3, NFKB1, NFKBIA, NQO1, PON3, PPARG, PPARGC1A, RAD51, SERPINH1, TNF, TRA1.

Chaperones and Heat Shock Proteins: BAG1, CALR, CANX, CCT2, CCT3, CCT4, CCT5, CCT7, CCT8, CRYAA, CRYAB, DNAJA1, DNAJA2, DNAJA3, DNAJA4, DNAJB1, DNAJB11, DNAJB2, DNAJB4, DNAJB5, DNAJB9, DNAJC4, DNAJC5, DNAJC7, DNAJC8, HSF1, HSPA1A, HSPA1L, HSPA2, HSPA4, HSPA6, HSPA8, HSPA9B, HSPB1, HSPB2, HSPB3, HSPCA, HSPCB, HSPD1, HSPE1, HSPH1, HYOU1, SERPINH1, ST13, TCP1, TRA1.

Transcription Factors and Regulators:
Ligand-dependent Nuclear Receptors: AHR, ESR1, ESR2, NR1I2, NR1I3, PPARD, PPARG, PPARGC1A, RARA, RARB, RARG, RXRA, RXRB, RXRG.
Other Transcription Factors and Regulators: ABL1, AR, ARNT, BRCA1, BRCA2, CALR, CCNC, DDIT3, E2F1, EGR1, ELK1, ERCC3, FOS, HIF1A, HOP, HSF1, MYC, MYST2, MYST4, NFKB1, NFKB2, NFKBIA, NFKBIB, RB1, RELB, SAFB, TNF, TP53.

Drug Metabolizing Enzymes:
Acyltransferases: ACAT1, CHAT, CRAT, DLAT, HAT1, NAT1, NAT2, NAT5.Methyltransferases: COMT, HNMT, MGMT, NNMT, TPMT, TYMS.
Sulfotransferases: CHST1, CHST10, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, GAL3ST1, SULT1A1, SULT1B1, SULT1C1, SULT1C2, SULT1E1, SULT2A1, SULT2B1, SULT4A1, TPST1, TPST2.
Oxidoreductases: ACADSB, CAT, CYP11A1, CYP11B2, CYP1A1, CYP1A2, CYP1B1, CYP20A1, CYP24A1, CYP26B1, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP3A4, CYP3A5, CYP4A11, CYP4B1, CYP4F3, CYP7A1, CYP7B1, CYP8B1, DHFR, DIA1, DPYD, FMO1, FMO4, FMO5, GPX1, GPX2, GSR, HMOX1, HMOX2, MAOA, MAOB, NOS2A, NQO1, POR, PRDX1, PRDX2, PTGS1, PTGS2, SOD1, SOD2, SRD5A2, TBXAS1, XDH.
Glutathione Peroxidases: GPX1, GPX2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM5, GSTO1, GSTP1, GSTT1, GSTT2, MGST1, MGST2, MGST3.

Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

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