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Potential Diagnosis Markers

Cell Cycle:
Cell Cycle Arrest and Checkpoint: MYC, RB1, TP53.
Negative Regulation of the Cell Cycle: ATM, BAX, BRCA1, EGFR, ESR1, NME1, PTEN, RB1, TP53.
Regulation of the Cell Cycle: BCL2, BRCA2, CCND1, CCNE1, CDK4, FGF3, FGF8, IGF2, MAPK3, PCNA, PRKCA, TGFA, TGFB1, TGFB2, TGFB3, VEGF.
DNA Replication: CDK2, EGF, IGF1, PCNA.

Cell Growth and Proliferation:
Growth Factors and Cytokines: BMP6, CSF1, CSF3, EGF, FGF18, FGF3, FGF8, IGF1, IGF2, TGFA, TGFB1, TGFB2, TGFB3, TNF, VEGF.
Positive Regulation of Cell Proliferation: CDK2, CSF1, CSF3, EGF, FGF18, FGF3, IGF1, VEGF.
Negative Regulation of Cell Proliferation: BCL2, NME1, ODZ1, PLG.
Regulation of Cell Growth: ESR2, IGFBP3, TP53, TSG101,
Other Genes Involved in Cell Growth and Proliferation: AR, BRCA1, CDK4, EGFR, ERBB2, ERBB4, ESR1, MYC, PCNA, PRKD1, PRL.

Cell Differentiation: CSF1, IGFBP3, TP53.

Apoptosis:
Induction of Apoptosis: BAX, MX1, PRKCA, PRKCE, TP53.Anti-apoptosis: AKT1, BAG3, BCL2, BCL2L1, PRKCZ, TGFB1, TNF.
Other Apoptosis Genes: BRCA1, IGFBP3, VEGF.

DNA Repair: ATM, BRCA1, BRCA2, PCNA, RAD51, TP53, XRCC3.

Angiogenesis Factors: FGF3, VEGF.

Cell Adhesion Molecules: CD34, CDH1, CTNNB1, ITGB3, PECAM1.

Extracellular Matrix (ECM) Molecules: ALB, BRCA1, BRCA2, COL4A2, CSF3, CTSD, EGF, ERBB2, FGF18, FGF3, FGF8, IGF1, IGF2, IGFBP3, INS, KLK13, MMP11, MMP9, ODZ1, PRL, SERPINE1, SHBG, TGFA, VEGF.

Protein Kinases: AKT1, ATM, CDK2, CDK4, EGFR, ERBB2, ERBB3, ERBB4, MAPK3, PDPK1, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCZ, PRKD1, PRKD2, SRC, TYK2.

Protein Phosphatases: IGFBP3, PTEN.

Transcription Factors and Regulators: AR, BRCA1, BRCA2, CTNNB1, EGR3, ESR1, ESR2, FOS, JUN, MYC, NR4A1, PCNA, PGR, RB1, SP1, TNF, TP53, TSG101.

Proteases and Protease Inhibitors: CTSB, CTSC, CTSD, CTSE, CTSL2, KLK13, MMP11, MMP9, PCSK6, PLG, SERPINE1.

Other Potential Diagnostic Markers: ABCB1, ABCG2, AKAP1, CEACAM5, CYB5, CYC1, CYP19A1, GSTM1, GSTM3, KRT18, KRT19, MIB1, MUC1, MUC19, PALM2-AKAP2, VIM.

Potential Prognosis Markers

Cell Cycle:
Cell Cycle Arrest and Checkpoint: CCNE2.
Negative Regulation of the Cell Cycle: ESR1, EXT1.
Regulation of the Cell Cycle: BCL2, CCNB1, CCNB2, CDC25B, CENPF, MKI67, MYBL2, PCTK1, PSMD2, TGFB3, VEGF.
DNA Replication: MCM6, ORC6L, RFC4, RRM2.
Other Cell Cycle Genes: BIRC5, BUB1, CKS2, MAD2L1, SMC4L1, STK6.

Cell Growth and Proliferation:
Growth Factors and Cytokines: ESM1, FGF18, TGFB3, VEGF.
Positive Regulation of Cell Proliferation: CDC25B, FGF18, FLT1, VEGF.
Negative Regulation of Cell Proliferation: BCL2, BTG2.
Regulation of Cell Growth: CHPT1, ESM1, IGFBP5, WISP1.
Other Genes Involved in Cell Growth and Proliferation: BUB1, CKS2, ESR1, MAPRE2, MKI67.

Cell Differentiation: NDRG1.

Apoptosis:
Anti-Apoptosis: BAG1, BCL2, BIRC5, BNIP3, MYBL2.
Other Apoptosis Genes: RAD21, STK3, VEGF.

DNA Repair: BTG2, RAD21.

Angiogenesis Factors: FLT1, VEGF.

Cell Adhesion Molecules: WISP1.

Extracellular Matrix (ECM) Molecules: ADM, COL4A2, CP, ESM1, FGF18, FLT1, IGFBP5, MATN3, MMP11, MMP9, RBP3, TFRC, VEGF, WISP1.

Protein Kinases: BUB1, CCNE2, CDC42BPA, CKS2, FLT1, MELK, PCTK1, STK3, STK32B, STK6.

Protein Phosphatases: CDC25B, MTMR2.

Transcription Factors and Regulators: BTG2, ESR1, EZH2, HMGB3, IVNS1ABP, KIAA1442, MCM6, MLLT10, MYBL2, PGR, PIR, SEC14L2, TBX3, TRIP13.

Proteases and Protease Inhibitors: BIRC5, CTSL2, GGH, MMP11, MMP9, PCSK6, PITRM1, RBP3, TFRC, UCHL5.

Other Potential Prognostic Markers: ACADS, ALDH4A1, ALDH6A1, AP2B1, ASNS, ASPM, BBC3, BM039, C20orf103, C20orf28, C20orf46, CA9, CD68, CENPA, CIRBP, CTPS, DCK, DEGS, DEPDC1, DKFZP434B168, DKFZp762E1312, DLG7, ECT2, EGLN1, EIF2C2, ERP70, EVL, FBP1, FBXO31, FBXO5, FGD6, FLJ10134, FLJ10156, FLJ10511, FLJ10901, FLJ12150, FLJ21924, FLJ22341, FUT8, GBE1, GCN1L1, GMPS, GNAZ, GPR126, GPSM2, GRB7, GSTM1, GSTM3, HRASLS, HRB, IHPK2, ITR, KIAA0882, KIAA1181, KIAA1217, KIAA1324, KIAA1683, KIF14, KIF21A, KIF3B, KNTC2, KRT18, LCHN, LGP2, LOC388134, LOC56901, LYRIC, M160, MCCC1, MGAT4A, MIR, MLF1IP, MRPL13, MS4A7, MYRIP, NMB, NMU, NUSAP1, ODZ3, OXCT, PALM2-AKAP2, PAQR3, PECI, PEX12, PFKP, PGK1, PIB5PA, PLEKHA1, PRAME, PRC1, PRO2000, PSMD7, PTDSS1, PTPLB, QDPR, RAB27B, RAB6B, RAI2, RAMP, RASL11B, RPS4X, RRAGD, SACS, SCUBE2, SERF1A, SLC2A3, SLC7A1, Spc25, ST7, STMN1, STX1A, SYNCRIP, TK1, TMEFF1.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

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