Apoptosis: Anti-Apoptosis: AKT1, BCL2, BRAF, CCL2, FOXO1A, HDAC1, IER3, IGF1R, MYBL2, NFKB1, NOTCH2, PEA15, RELA, SEMA4D, TGFB1, TNF, TNFRSF6, VHL. Caspase Activation: F2R, STAT1, TNFRSF10A, TNFRSF10B. Induction of Apoptosis Resulting From DNA Damage Response Signal Transduction: ABL1, TP53, TP73. Induction of Apoptosis: DCC, NME3, BAX, NOTCH2, TNFRSF10A, TNFRSF10B, TNFRSF6, TRADD. Induction of Apoptosis by Signals: Intracellular and Extracellular, by Death Domain, and by Hormones: BTK, TIMP3, BAX, FASTK, SIVA TP53, CDKN1A, CUL1, TNFRSF10A, TNFRSF10B. Regulation of Apoptosis: BAX, BCL2, BRCA1, PEA15, TNFRSF10B, TNFRSF6. Factors Involved in Other Aspects of Apoptosis: BRCA1, E2F1, FASTK, IL1B, RAF1, RIPK1, SIVA, TNFRSF1A, TNFRSF1B, TNFSF7, TP53BP2, TRADD, BAX, BCL2, F2R, IER3, NFKB1, PEA15, TNF, TNFRSF10A, TNFRSF10B, TNFRSF6, TP53, TP73. Other Apoptosis-Related Genes: VDAC1, BAX, VDAC1. Cell Cycle: Cell Cycle Arrest: CGRRF1, MYC, PA2G4, TBRG4, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2D, CUL1, MAPK12, NOTCH2. Cell Cycle Checkpoint: RB1, BRCA1, CDKN2A, TP53. Factors Involved in Other Aspects of the Cell Cycle: ATM, CCND1, CCND2, CCND3, CCNE1, CDC20, CDK4, CDK5, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2D, CHAF1A, E2F3, MAPK12, MAPK13, MCM2, PLK2, RBBP4, RBL2, SEPT6, TAF1, TFDP1, TFDP2, CDKN1A, CUL1, E2F1, TP53BP2. Regulation of the Cell Cycle: APC, ING1, KLK10, MCC, MSH2, NF1, NF2, NME1, NME2, PTCH, PTEN, RAP1A, WT1, ATM, BAX, BRCA1, CDKN1C, CDKN2A, CDKN2B, CDKN2D, DCC, MAPK12, RB1, RBL2, TP53, TP73, VHL, AXL, BRCA2, CDC25A, CDC25B, CDK9, CDKL1, CLK1, CSK, E2F5, FRAP1, GSPT1, IFITM1, KRAS2, LCK, MAPRE1, NRAS, PCNA, PCTK1, PCTK2, PDGFA, PDGFB, PIK3CB, PTMA, PTN, SFN, TGFA, VEGF, WEE1, ABL1, APC, ATM, BCL2, CCND1, CCND2, CCND3, CCNE1, CDC20, CDK4, CDKN1A, CDKN1B, E2F1, E2F3, F2R, IGF1R, IL1B, MYBL2, RAP1A, RB1, STAT1, TFDP1, TFDP2, TGFB1, TP53BP2, VHL. Cell Growth and Differentiation: Cell Differentiation and Cell Fate: NOTCH1, NOTCH4, NRG1, SKI, SKIL, NOTCH2. Cell Growth and Maintenance: ABL1, ABL2, ARHGEF5, AXL, BCL2, BRAF, CBFB, CCND1, CDK4, CSF1R, DEK, ETV1, ETV6, FES, FGFR1, FGR, FOS, FOXO1A, GNAS, IER3, IGFBP3, IGFBP4, IGFBP5, JUN, KIT, KRAS2, LCK, LYN, MAP3K8, MAS1, MDM2, MET, MLLT3, MYB, MYC, MYCN, NF1, NFKB2, NOTCH2, NPM1, NRAS, PDGFA, PDGFB, PHB, PIM1, RAF1, RARA, RARB, REL, RET, RHOA, RHOB, RHOC, SEMA3C, SKI, SKIL, SMO, SRC, TGFB1, VEGF, WNT1, WNT3, YES1. Cell Proliferation: CDC25, CCYR61, EGFR, ERBB2, ERBB4, GAS6, HDGF, KITLG, LRPAP1, MT3, OSM, PDGFRA, TGFBI, CDC25A, CDK4, CDK5, CDK9, CLK1, CSF1R, E2F1, FES, GSPT1, IGFBP4, IL1B, MAPRE1, MAS1, MET, MYC, PA2G4, PCNA, PDGFA, PDGFB, PTCH, PTN, RAF1, SFN, TFDP1, TGFA, TGFB1, NFSF7, VEGF. Growth Factors: GDF15, HDGF, IL1B, KITLG, NRG1, PDGFA, PDGFB, PTN, TGFA, TGFB1, VEGF. Regulation of Cell Proliferation, Differentiation, Growth, and Volume: BCL2, BRCA1, CAPN1, CAPNS1, CDC25B, CDC2L5, CDK10, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2D, CGRRF1, CLNS1A, CUL1, CYR61, DLG3, FOSL1, IFITM1, IGF1R, IGFBP3, IGFBP4, IGFBP5, IL1B, MDM2, MDM4, MT3, NF1, NF2, NME1, NME2, NOTCH2, NOTCH4, OSM, PTN, RBBP4, SOCS1, SOCS3, TBRG4, TGFBR2, TIMP1, TOB1, TSG101, VEGF, VHL. Cell Motility: Cell Migration and Motility: FN1, GNA13, HMMR, NEO1, RAC1, SPINT2, STAT3, THBS1, TPBG, F2R. Cell-Cell Adhesion: CD44, ICAM1. Cell-Matrix Adhesion: ILK, ITGA3, ITGA6, ITGB4, NID, CD44. Metalloendopeptidases (MMPs) and MMP inhibitors: ACY1, ANPEP, MME, MMP1, MMP14, MMP17, MMP2, PA2G4, TIMP1, TIMP3. Signal Transduction: Cell Surface Receptor-Linked Signal Transduction: CBLB, CD59, FZD2, FZD5, FZD9, MYD88, STC1, CCL2, FGFR1, IFITM1, PDGFA, PDGFRA, SMO. Frizzled and Frizzled-2 Signaling Pathways: DVL1, DVL3, TLE1, FZD9, WNT2, WNT2B, WNT5A, WNT1, WNT3. G-Protein Coupled Receptor (GPCR) Protein Signaling Pathway: CRHR1, GNB2, GPR39, NMBR, PIK3CG, RGS19, AKT1, CCL2, F2R, FZD2, FZD5, FZD9, GNA13, GNAS, MAS1, PIK3CB, SMO. Insulin Receptor Signaling Pathway: PDPK1, IGF1R. Integrin-Mediated Signaling Pathway: ILK, ITGA3, ITGA6, ITGB4. Intracellular Signaling Cascade: FKBP8, GRB2, JAK1, PRKAR1A, RASGRF1, SHB, STAT2, STAT5B, ZAP70, ABL1, ABL2, BRAF, BTK, CBLB, CSK, DVL1, DVL3, FES, FGR, LCK, LYN, RAC1, RAF1, SOCS1, SOCS3, SRC, STAT1, STAT3, YES1. JAK-STAT Cascade: CCL2, SOCS1, STAT1, STAT2, STAT3, STAT5B. Notch Signaling Pathway: NOTCH2, NOTCH4. RAS Protein Signal Transduction: GRB2, LCK, NF1. Rho Protein Signal Transduction: ARHGAP5, RHOD, RHOA, RHOB. Small GTPase-Mediated Signal Transduction: ACK1, RAB5A, SIAH2, KRAS2, NRAS, RAC1, RAP1A, RASGRF1, RGS19, RHOA, RHOB, RHOC, RHOD. Wnt Receptor Signaling Pathway: CSNK1G2, CTNNB1, FRZB, TCF7L2, APC, DVL1, DVL3, FZD2, FZD5, FZD9, TLE1, WNT1, WNT2, WNT2B, WNT3, WNT5A. Other Cancer-Related Genes: AARS, ABCB1, ABCC4, ABI2, ACP2, ADSL, AK1, AKR1C2, ALB, ANXA5, ANXA7, AP2M1, ARID4A, ASNS, ATF4, ATP5B, ATP5O, BARD1, BHLHB2, BLMH, CANX, CAP1, CAV1, CCT5, CD24, CEBPG, CENPC1, CIB1, CKMT1, CLK2, CLK3, CLTC, COL1A1, COL6A3, COX6C, COX7A2, CRAT, CTNNA1, CTPS, CTSC, CTSD, DCN, DDX10, DHCR7, DHRS2, DHX8, EGR1, EIF5, EPHA2, ERBB3, ERCC3, ETV3, FBN1, FBN2, FOSL2, FOXG1A, FTL, G22P1, GCN5L2, GNB2L1, GSK3A, GTF2I, HPRT1, HRB, HSPA4, HSPA5, HSPA8, HSPB1, HSPH1, HYAL1, HYOU1, ID1, ID2, IDUA, IGF2R, IRF3, JARID1A, JUNB, JUND, K-ALPHA-1, KPNA2, KRT18, KRT2A, KRT9, LAMB1, LAMP2, LCN2, LEP, LITAF, LTF, LZTR1, MADH1, MAP2K2, MAPKAPK3, MARS, MCM4, MGST1, MICB, MNDA, MSH6, MYBL1, MYCL1, MYL9, MYLK, NINJ1, NQO1, NR1D1, NR2F1, NR2F6, NSEP1, PABPC1, PCTK3, PFDN4, PFDN5, PGAM1, PIK3CA, PKM2, PKMYT1, PPARD, PPARG, PPIH, PPP1CA, PPP2R5A, PRDX2, PRDX4, PRKCBP1, PRNP, PRSS15, PSMA1, PTGS1, PTPRN, RAD50, RALBP1, REA, RELB, RFC2, RPN2, RPS6KB1, RRM1, SARS, SELENBP1, SEPP1, SERPINH1, SFPQ, SFRS7, SHH, SLC16A1, SLC1A4, SLC20A1, SMPD1, SNAI2, SND1, SNRPB2, SOD1, SORT1, SPRY2, SRPX, TBL3, TCF1, TFAP2C, TGFBR3, TIE, TJP1, TK1, TNK1, TP53I3, TPT1, TRAM1, TRRAP, TUFM, TXNRD1, TYRO3, UBC, UBE2L6, UCHL1, USP7, VIL2, XRCC1, YWHAB, YWHAZ, ZNF9. |
