Mouse Endothelial Cell Biology

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Oligo GEArray® Mouse Endothelial Cell Biology Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OMM-015
HybPlate Format Cat. No.: EMM-015

Description

The Oligo GEArray® Mouse Signal Transduction PathwayFinder™ Microarray profiles the expression of 113 genes representative of the 18 signal transduction pathways listed below. Through a simple side-by-side hybridization experiment you can simultaneously determine which of the 18 signal transduction pathways is involved in your experimental treatment. Once you have identified the pathways involved in your treatment with this microarray, you can then perform focused profiling experiments using our pathway-specific GEArray® Microarrays. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

Related Products for the Genes on This Array

shRNA Plasmids

qPCR Gene Assays

Modify This Array

Functional Gene Grouping

Mitogenic Pathway: Egr1 (egr-1), Fos (c-fos), Jun (c-jun), Nab2.

Wnt Pathway: Birc5, Ccnd1 (cyclin D1), Cdh1, Fgf4, Jun (c-jun), Lef1, Myc (c-myc), Pparg, Tcf7, Vegfa, Vegfc, Wisp1, Wisp2.

Hedgehog Pathway: Bmp2, Bmp4, En1 (engrailed), Foxa2 (forkhead box A2 / HNF3B), Hhip, Ptch (patched 1), Ptch2 (patched 2), Wnt1, Wnt2, Wsb1.

TGF-β Pathway: Cdkn1a (p21^Waf1, p21^Cip1), Cdkn1b (p27), Cdkn1c (p57^Kip2), Cdkn2a (p16^Ink4,), Cdkn2b (p15 ^Ink2b), Cdkn2c (p18, cdk4 inhibitor), Cdkn2d (p19).

Survival Pathway:
PI3 Kinase / AKT Pathway: Bcl2 (Bcl-2), Ccnd1, Fn1 (fibronectin), Jun (c-jun), Mmp7 (matrilysin), Myc (c-myc), Pten.
Jak / Src Pathway: Bcl2 (Bcl-2), Bcl2l1 (Bcl-XL).
NFκB Pathway: Birc1a, Birc1b, Birc2 (c-IAP2), Birc3 (c-IAP1), Tert.

p53 Pathway: Bax, Cdkn1a (p21, p21^Cip1), Ei24 (Pig3), Gadd45a (gadd45), Igfbp3, Mdm2, Tnfrsf6 (Fas), Tnfrsf10b (TrailR/DR5).

Stress Pathway: Atf2, Fox (c-fos), Hsf1 (tcf5), Hsp90-Rik, Hspb1 (Hsp25), Myc (c-myc), Trp53 (p53).

NFκB Pathway: Ccl20, Cxcl1, Icam1, Ikbkb, Il1a, Il2, Lta (TNFβ), Nfkb1, Nfkbia, Nos2 (iNOS), Tank, Tnf (TNF&aplha;), Vcam1.

NFAT Pathway: Cd5, Il2, Tnfsf6 (FasL).

CREB Pathway: Cyp19a1, Egr1 (egr-1), Fos (c-fos).

Jak-Stat Pathway: Csnb, Cxcl9 (MIG), Il4, Il4ra, Irf1, Mmp10 (stromelysin-2), Nos2 (iNOS), Pzp.

Estrogen Pathway: Bcl2 (Bcl-2), Brca1, Ctsd (cathepsin D), Cxcl12, Egfr, Greb1, Igfbp4, Nrip1, Pgr (PR), Trim25.

Androgen Pathway: Cdk2, Cdkn1a (p21^Waf1, p21^Cip1), Egfr, Klkb1 (Klk3), Tmepai.

Calcium and Protein Kinase C Pathway: Csf2 (GM-CSF), Fox (c-fos), Il2, Il2ra (IL-2 Ra), Jun (c-jun), Myc (c-myc), Odc, Prkca, Prkce (PKCE), Tfrc.

Phospholipase C Pathway: Bcl2 (Bcl-2), Egr1, Fox (c-fos), Icam1, Jun (c-jun), Junb, Nos2 (iNOS), Ptgs2 (cox-2), Vcam1.

Insulin Pathway: Cebpb (C/EBP-β), Fasn (fatty acid synthase), Gys1 (GS, glycogen synthase), Hk2 (hexokinase II), Lep (Ob).

LDL Pathway: Ccl2, Csf2 (GM-CSF), Sele, Selp (P-selectin), Vcam1.

Retinoic Acid Pathway: Cdx1, Ctsd (cathepsin D), En1 (engrailed), Hoxa1, Hoxb1, Rbp1 (CRBPI), Rbp2 (CRABPII), Stra6, Stra8.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

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Smalley MJ, Dale TC. (1999) Wnt Signaling in Mammalian Development and Cancer. Cancer Metastasis Rev 18(2): 215-30.
McMahon AP (2000) More Surprises in the Hedgehog Signaling Pathway. Cell 100:185-188.
Landesman Y, et al. (1997) Modifications of p53 Protein and Accumulation of p21 and gadd45 mRNA in TGF-b1 Growth Inhibited Cells. Cell Signal. 9(3-4): 291-8.
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el-Deiry WS. (1998) Regulation of p53 Downstream Genes. Semin Cancer Biol 8(5): 345-57.
Kovacs KJ, et al. (1998) c-Fos as a Transcription Factor: a Stressful (Re) View from a Functional Map. Neurochem Int. 33(4): 287-97.
Tayor BS, et al. (1998) Multiple NF-kB Enhancer Elements Regulate Cytokine Induction Of The Human Inducible Nitric Oxide Synthase Gene. J Biol Chem. 273(24): 15148-56.
Chow CW, et al. (1999) Requirement for Transcription Factor NFAT In Interleukin-2 Expression. Mol Cell Biol. 19(3): 2300-7.
Ahn S, et al. (1998) A Dominant-Negative Inhibitor Of CREB Reveals That It Is A General Mediator Of Stimulus-Dependent Transcription Of c-Fos. Mol Cell Biol. 18(2): 967-77.
Chida D, et al. (1998) Transcriptional Regulation Of The Beta-Casein Gene By Cytokines: Cross-Talk Between STAT5 And Other Signaling Molecules. Mol Endocrinol 12(11): 1792-806.
Muramatsu M, Inoue S. (2000) Estrogen Receptors: How Do They Control Reproductive and Nonreproductive Functions? Biochem Biophys Res Commun 270(1): 1-10.
Lindzey J, et al. (1994) Molecular Mechanisms of Androgen Action. Vitamins and Hormones 49: 383-432.
Roifman CM, et al. (1987) Induction of human B Cell Proliferation and Differentiation By the Combination of Phobol Ester and Ionomycin. Eur J Immunol 17(5): 701-6.
Chen CC, et al. (2000) TNF-Alpha-Induced Cyclooxygenase-2 Expression In Human Lung Epithelial Cells: Involvement Of The Phospholipase C-Gamma 2, Protein Kinase C-Alpha, Tyrosine Kinase, NF-Kappa B-Inducing Kinase, And I-Kappa B Kinase ? Pathway. J Immunol 165(5): 2719-28.
OÆBrien RM, Granner DK (1996) Regulation Of Gene Expression By Insulin. Physiol Rev 76(4): 1109-1161.
Allen S, et al. (1998) Native Low Density Lipoprotein-Induced Calcium Transients Trigger VCAM-1 And E-Selection Expression In Culrured Human Vascular Endothelial Cells. J. Clin. Invest. 101(5): 1064-1075.
Chiba H, et al. (1997) Distinct Retinoid X Receptor-Retinoic Acid Receptor Heterodimers Are Differentially Involved In The Control Of Expression Of Retinoid Target Genes In F9 Embryonal Carcinoma Cells. Mol Cell Biol 17: 3013-20.