Mouse TGFβ BMP Signaling Pathway

Research Area

Browse by Pathway

Browse by Disease

Oligo GEArray® Mouse TGFβ BMP Signaling Pathway Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OMM-035
HybPlate Format Cat. No.: EMM-035

Description

The Oligo GEArray® Mouse TGFb BMP Signaling Pathway Microarray contains 113 genes, which encode members of the TGFb superfamily and key proteins involved in the TGFb signal transduction pathway. The TGFb superfamily of cytokines influences a diverse range of normal cellular processes, such as cell adhesion, cell proliferation, apoptosis, and secretion of extracellular matrix molecules. In addition, they are key molecules in many developmental processes, including body plan determination in embryos and organ morphogenesis in adults. Alteration of the signaling pathway has been linked to different disease processes, including developmental abnormalities and cancer progression. Determine which genes related to the TGFb BMP Signaling Pathway are differentially expressed among your experimental samples using this array.

Need more information about GEArray products? please visit Microarray Home or send Email to Technical Support

Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

Related Products for the Genes on This Array

shRNA Plasmids

qPCR Gene Assays

Modify This Array

Functional Gene Grouping

TGFß superfamily cytokine:

TGF-ß: Tgfb1, Tgfb2, Tgfb3.

BMP: Bmp1, Bmp10, Bmp15, Bmp2, Bmp3, Bmp4, Bmp5, Bmp6, Bmp7, Bmp8a, Bmp8b.

GDF: Amh, Cdc25a, Dlx2, Gdf1, Gdf10, Gdf11, Gdf15, Gdf2, Gdf3, Gdf5, Gdf6, Gdf7, Gdf8, Gdf9, Igf1, Igfbp3, Il6, Ltbp1, Ltbp2, Ltbp4, Myc, Pdgfb, Smurf1.

Activin: Inha, Inhba, Inhbb, Inhbc, Inhbe, Lefty1, Lefty2, Nodal.

Receptor:

Acvr1, Acvr1b, Acvr1c, Acvr2, Acvr2b, Acvrl1, Amhr2, Bmpr1a, Bmpr1b, Bmpr2, Cd79a, Igfbp3, Itgb5, Itgb7, Nr0b1, Tgfb1i1, Tgfbr1, Tgfbr2, Tgfbr3, Tgfbrap1.

SMAD:

Smad1, Smad2, Smad3, Smad4, Smad5, Smad6, Smad7, Smad9.

Smad target gene:

TGF-ß/Activin responsive: Cd79a, Cdc25a, Cdkn1a, Cdkn2b, Col1a1, Col1a2, Col3a1, Fos, Gsc, Igf1, Igfbp3, Il6, Itgb7, Ivl, Jun, Junb, Myc, Pdgfb, Plat, Plau, Serpine1, Tgfb1i1, Tgfb1i4, Tgfbi, Tgif, Timp1.

BMP responsive: Bglap2, Dlx2, Idb1, Idb2, Idb3, Idb4, Junb, Smad6, Sox4, Stat1, Zfhx1a.

Molecules regulating signaling of TGF-ß superfamily:

Bambi, Bmper, Cdkn2b, Cer1, Chrd, Eng, Evi1, Fkbp1b, Fst, Grem1, Lap3, Ltbp4, Nbl1, Nog, Runx1, Runx2, Smurf1, Smurf2.

Adhension and Extracellular Molecules:

Adhension Molecules: Eng, Itgb5, Itgb7, Tgfbi.

Extracellular matrix structural constituent: BCol1a1, Col1a2, Col3a1, Ltbp1, Ltbp4, Tgfb1, Tgfb2, Tgfbi, Timp1 .

Other extracellular molecules: Acvr1b, Acvr2, Acvr2b, Acvrl1, Amhr2, Bglap2, Bmp1, Bmp10, Bmp15, Bmp2, Bmp4, Bmp5, Bmp6, Bmp7, Bmp8a, Bmp8b, Bmper, Bmpr1a, Cer1, Chrd, Eng, Fst, Gdf1, Gdf10, Gdf11, Gdf15, Gdf2, Gdf3, Gdf5, Gdf6, Gdf9, Grem1, Igf1, Igfbp3, Il6, Inha, Inhba, Inhbb, Inhbc, Inhbe, Itgb5, Itgb7, Lefty1, Lefty2, Nbl1, Nodal, Nog, Pdgfb, Plat, Plau, Serpine1, Tdgf1, Tgfb3, Tgfbr1, Tgfbr3.

Transcription Factors and Regulators:

Dlx2, Fos, Gsc, Idb1, Idb3, Jun, Junb, Myc, Nr0b1, Runx1, Runx2, Smad1, Smad2, Smad3, Smad4, Smad5, Smad6, Smad7, Smad9, Sox4, Stat1, Tgfb1i1, Tgfb1i4, Tgif, Zfhx1a.

Genes Involving in Cellular/ Developmental Processes:

Apoptosis: Cdkn1a, Igf1, Igfbp3, Il6, Inha, Myc.

Embryonic development: Acvr1, Acvr1b, Bmp10, Bmp2, Bmp4, Bmp5, Bmp7, Bmpr1a, Chrd, Grem1, Nodal, Nog, Smad2, Smad3, Smad4, Smurf1, Tdgf1, Tgfb3, Tgfbr1.

Muscle development: Smad3, Tgfb1.

Neurogenesis: Bmp4, Chrd, Fos, Igf1, Inha, Nog, Runx1.

Reproduction: Amhr2, Bmp8a, Bmp8b, Bmpr1a, Fst, Inha, Inhbb, Smad1.

Skeletal development: Bglap2, Bmp4, Bmp5, Bmpr1b, Chrd, Nog, Runx2, Tgfb1.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

Miyazono K, Kusanagi K, Inoue H., Divergence and convergence of TGF-beta/BMP signaling, J Cell Physiol 2001 Jun; 187 (3): 265-76
Miyazono K., Positive and negative regulation of TGF-beta signaling, J Cell Sci 2000 Apr; 113 (Pt 7): 1101-9
Massague J, Blain S, Lo R, TGFb signaling in growth control, cancer, and heritable disorders, Cell 2000 Oct; 103: 295-309
Wrana J, Regulation of Smad activity, Cell 2000 Jan; 100: 189-192
Ring C, Cho K, Specificity in transforming growth factor-b signaling pathways, Am J Hum Genet 1999 64: 691-697