Mouse JAK / STAT Signaling Pathway

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Oligo GEArray® Mouse JAK / STAT Signaling Pathway Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OMM-039
HybPlate Format Cat. No.: EMM-039

Description

The Oligo GEArray® Mouse JAK / STAT Signaling Pathway Microarray is designed to systematically study Jak- and Stat-mediated signaling. The array represents all known Jak and Stat family members and the receptors that activate them. The nuclear co-factors and co-activators associated with the Stat proteins, Stat-inducible genes, and negative regulators of the pathway are also included. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

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shRNA Plasmids

qPCR Gene Assays

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Functional Gene Grouping

JAK and STAT Proteins:
Janus Kinase Activity: Jak1, Jak2, Jak3, Tyk2.
STAT Family: Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, Stat6.

Receptors that Bind and Activate JAK Proteins: Aps, Csf1r, Csf2rb2, Cxcl9 (MIG), E230031K19, Egfr, Epor, F2r, Fcer1a, Fcer2a, Fcgr1, Ghr, Ifnar1, Ifnar2, Ifngr1, Ifngr2, Il10ra, Il10rb, Il22ra1, Il2ra, Il2rg, Il31ra, Il4ra, Il6st, Insr, Mpl (TPOR), Nr3c1, Pdgfra, Prlr, Ptprc (CD45), Tnfrsf6.

SH3/SH2 Adaptor Protein Activity: Aps, Sit, Sla2.

STAT Protein Nuclear Translocation: Jak2, Prl.

Genes Involved in Tyrosine Phosphorylation of STAT Protein: Bsf3, Il20, Il31ra, Jak2, Prlr.

Transcription Factors or Regulators that Interact with STAT Proteins:
Positive Regulation of Transcription: Ifng, Il31ra, Irf1, Jun, Maf, Smad2, Smad3, Smad4.
Negative Regulation of Transcription: Nfkb1, Pias4, Sla2, Smad3.
RNA Polymerase II Transcription Factor Activity: Miz1 (PIASxb), Smad1.
Crebbp (CBP), Il31ra, Ncoa1.
Transcriptional Activator Activity: Ifng, Stat3.
C2ta (CIITA), Cebpb (C/EBPb), Gata3, Hmga1 (HMGIY), Ifnar2, Isgf3g (p38 / IRF9), Junb, Mcm5, Myc, Nr3c1, Sfpi1 (PU.1), Smad5, Smad6, Smad7, Smad9, Sp1, Usf1, Yy1.

Genes Induced by STAT Proteins:
Stat1: C2ta (CIITA), Cxcl9 (MIG), Indo, Irf1, Nos2.
Stat3: A2m, Bcl2l1 (Bcl-xl), Cdkn1a (p21), Crp, Irf1, Junb, Mmp3, Myc, Pzp, Saa3, Socs1, Tnfrsf6.
Stat4: Fcer2a, Fcgr1, Ifng, Irf1, Myc.
Stat5: Ccnd1, Cdkn1a (p21), Csnb (b-casein), Il2ra, Irf1, Osm, Pim1.
Stat6: Fcer1a, Gata3, Il4, Il4ra, Maf.
Stat1/Stat2/p48 (ISGF3): G1p2, Indo, Oas1a.

Negative Regulators of the JAK/ STAT Pathway: Miz1 (PIASxb), Pias1, Pias3, Pias4, Ptpn1 (PTP1B), Ptpns1, Ptprc (CD45), Socs1, Socs2, Socs3, Socs4, Socs5, Socs6, Socs7.

Apoptosis: Bcl2l1, Bsf3, Cdkn1a (p21), Cebpb (C/EBPb), Ifng, Il31ra, Il4, Jak2, Myc, Nfkb1, Prlr, Tnfrsf6.

Cell Differentiation: Bsf3, Ccnd1, Cebpb (C/EBPb), Gata3, Il20, Il31ra, Il4, Jak2, Jun, Nos2 (iNOS), Prlr, Ptprc (CD45), Sfpi1 (PU.1), Smad2, Socs2, Socs5, Stat3, Stat5a, Stat5b.

Cell Growth and/or Maintenance:
Cell Cycle: Ccnd1, Cdkn1a (p21), Jun, Junb.
Cell Proliferation: Ifnar2, Il2ra, Il31ra, Jak2, Myc, Ptprc (CD45), Scap2, Stat4, Stat6.
Cell Growth: Egfr, Ifng, Il4, Osm, Pdgfra, Socs1, Socs2, Socs3, Socs4, Socs5, Socs6, Socs7.

Immune Response:
Acute-Phase Response: Crp, F2, Saa3, Stat3.
Antigen Processing: Fcer1a, Fcer2a, Fcgr1.
Humoral Immune Response: Il4, Sla2.
Inflammatory Response: Cebpb (C/EBPb), Cxcl9 (MIG), Ifng, Il20, Il2ra, Irf1, Nfkb1, Nos2.
Lymphocyte Activation: Ifng, Il4, Prlr, Sit, Sla2.Other Genes Involved in Immune Response: G1p2, Gbp1, Il31ra, Il4ra, Indo, Isgf3g (p38 / IRF9), Oas1a, Osm, Tnfrsf6.

Other Proteins that Interact with STAT Proteins: Crk, Crkl, Nmi, Sh2bpsm1, Src, Stam, Stub1.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002 Feb 20; 285 (1-2): 1-24.
O'Shea JJ, Gadina M, and Schreiber RD. Cytokine signaling in 2002: New surprises in the Jak/Stat pathway. Cell. 2002 Apr; 109 Suppl: S121-31.
Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol. 2000 Jan-Feb; 37(1-2): 1-11.
Ward AC, Touw I, Yoshimura A. The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood. 2000 Jan 1; 95 (1): 19-29.
Mascareno E, Siddiqui MA. The role of Jak/STAT signaling in heart tissue renin-angiotensin system. Mol Cell Biochem. 2000 Sep; 212 (1-2): 171-5.