Mouse Asthma

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Oligo GEArray® Mouse Asthma Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OMM-067
HybPlate Format Cat. No.: EMM-067

Description

The Oligo GEArray® Mouse Asthma Microarray profiles the expression of 113 genes involved in asthma. Genes involved in the abnormally robust immune response that is characteristic of the disease are represented on this array. These genes include cytokines and their receptors and other immune response genes. Genes involved in the allergic response to biotic, chemical, and viral stimuli are included as well. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

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Functional Gene Grouping

Cytokines:
Chemokines: Ccl1, Ccl11, Ccl17, Ccl19, Ccl2, Ccl20, Ccl22, Ccl24, Ccl3, Ccl4, Ccl5, Ccl6, Ccl7, Ccl8, Cx3cl1, Cxcl1, Cxcl2, Xcl1.
Interferons: Ifna1, Ifnb1, Ifng, Ifngr1.
Interleukins: Csf3, Il10, Il11, Il12a, Il12b, Il13, Il15, Il16, Il17, Il18, Il19, Il1a, Il1b, Il2, Il21, Il2ra, Il2rg, Il3, Il4, Il5, Il6, Il7, Il9.
Tumor Necrosis Factor family: Cd40lg, Fasl, Lta, Tnf, Tnfsf12, Tnfsf7, Tnfsf8.
Other Cytokines: Ccr2, Csf1, Csf2, Fgf2, Tgfb1, Txlna.

Cytokine Receptors:
Chemokine Receptors: Ccr2, Ccr3, Ccr4, Ccr5, Ccr6, Ccr7, Ccr8, Cx3cr1, Gpr2 (Ccr10), Il8rb, Xcr1.
Interferon Receptors: Ifna1, Ifnar2, Ifnb1, Ifngr1, Ifngr2, Il12b, Il12rb1, Il12rb2, Il13, Il13ra1, Il13ra2, Il15, Il21, Il2rg, Il4, Il4ra, Il5ra, Il6ra, Il6st, Il7, Il9, Il9r.
Interleukin Receptors: Il12rb1, Il12rb2, Il13ra1, Il13ra2, Il18r1, Il4ra, Il5ra, Il6ra, Il8ra, Il8rb, Il9r.

Immune Response:
IgE Binding: Fcer1a, Fcer1g, Fcer2a, Lgals3, Ms4a2.
IgE Receptors: Cysltr1, Fcer1a, Fcer2a, Ltb4r1, Ltb4r2, Ltbr.
Isotype Switching: Cd28, Cd40, Cd40lg, Icosl, Ifng, Il10, Il2, Il4, Msh2, Nbn, Swap70, Tbx21, Tgfb1.
T cell Activation: Cd28, Icosl, Il10, Il12b, Il15, Il18, Il2, Il2ra, Il4, Il7, Irf4, Itgal, Lck, Ptprc, Sftpd, Socs5, Syk, Tnfrsf7, Trat1.
T-helper 2 Type Immune Response: Il10, Socs5.
B cell Activation: Cd40, Cd40lg, Fcer1a, Fcer1g, Icosl, Il10, Il11, Il21, Il4, Il7, Msh2, Ptprc, Syk, Tnfrsf7.
Cytokine Biosynthesis: Cd28, Fcer1a, Fcer1g, Gata3, Icosl, Ifng, Il10, Il12b, Il18, Il19, Il1b, Il2ra, Il6, Il9, Irf4, Ptprc, Sftpd, Syk, Tnfrsf7.
Humoral Immune Response: Ccr2, Cd28, Il12b, Lta, Tnf.
Other Genes Involved in the Immune Response: Ccl1, Ccl11, Ccl17, Ccl19, Ccl2, Ccl20, Ccl22, Ccl24, Ccl3, Ccl4, Ccl5, Ccl6, Ccl7, Ccl8, Ccr4, Ccr7, Csf2, Csf3, Cx3cl1, Cxcl1, Cxcl2, Fasl, Il12a, Il13, Il17, Il1a, Il3, Il4ra, Il5, Tnfsf12, Tnfsf7, Tnfsf8, Xcl1.

Response to Stimulus:
Response to Biotic Stimulus: Fcer1g, Ifna1, Ifnb1, Ifng, Il10, Ptprc, Tnf.
Response to Chemical Stimulus: Ccl1, Ccl11, Ccl17, Ccl19, Ccl2, Ccl20, Ccl22, Ccl24, Ccl3, Ccl4, Ccl5, Ccl6, Ccl7, Ccl8, Ccr10, Ccr2, Ccr3, Ccr4, Ccr5, Ccr7, Ccr8, Cxcl2, Fcer1g, Ifng, Il16, Il1b, Il8ra, Il8rb, Sftpd, Xcl1.
Response to Virus: Ifna1, Ifnb1, Ifng, Il15.
Sensory Perception: Ccl1, Ccl11, Ccl19, Ccl2, Ccl20, Ccl22, Ccl24, Ccl3, Ccl4, Ccl5, Ccl6, Ccl7, Ccl8, Ccr2, Cxcl2, Il16, Il8rb, Tnf, Xcl1.
Other Genes Involved in the Response to Stimulus: Cd40lg, Cd86, Fcer2a, Icosl, Itgal, Lck, Msh2, Nbn, Tgfb1.

Th2 Cytokine Signaling Pathway: Fos, Gata3, Jak1, Jak3, Stat6, Tbx21, Tgfb1, Yy1.

Apoptosis:
Anti-apoptosis: Cd28, Cd40lg, Il10, Il4, Il7, Msh2, Tnfrsf7.
Induction of Apoptosis: Cd28, Fasl, Il18, Il19, Lck, Tnf, Tnfrsf7.
Other Genes Involved in Apoptosis: Cd40, Csf2, Fgf2, Ifng, Il2ra, Il3, Il6, Il8rb, Lta, Ltbr, Tnfsf12.

Transcription Factors and Regulators: Ccl5, Fos, Gata3, Ifnar2, Ifng, Il2, Il4, Irf4, Jak3, Nbn, Stat6, Tbx21, Tgfb1, Tnf, Yy1.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

Olivenstein, R., et al. (1999) IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash. J. Allergy Clin. Immunol. 103(2 Pt 1), 238-45.
Rosenwasser, L.J. and L. Borish. (1997) Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). Am. J. Respir. Crit. Care Med. 156(4 Pt 2), S152-5.
Wong, C.K., et al. (2001) Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol. 125(2), 177-83.
Hellman, C., et al. (2002) Down-regulated IL-5 receptor expression on peripheral blood eosinophils from budesonide-treated children with asthma. Allergy 57(4), 323-8.
Medoff, B.D., et al. (2002) IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol. 168(10), 5278-86.
Romagnani, S. (2002) Cytokines and chemoattractants in allergic inflammation. Mol Immunol. 38(12-13), 881-5.
Teran, L.M., et al. (1999) Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am. J. Respir. Cell. Mol. Biol. 20(4), 777-86.
Zou, J., et al. (2002) Microarray profile of differentially expressed genes in a monkey model of allergic asthma. Genome Biol, 3(5), 20.
Owen, C. (2001) Chemokine receptors in airway disease: which receptors to target? Pulm. Pharmacol. Ther. 14(3), 193-202.
Ochi, H., et al. (1999) T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med. 190(2), 267-80.
Panina-Bordignon, P., et al. (2001) The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 107(11), 1357-64.
Ray, A. and L. Cohn. (1999) Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J Clin Invest. 104(8), 985-93.
Spinozzi, F., et al. (1998) Defective expression of Fas messenger RNA and Fas receptor on pulmonary T cells from patients with asthma. Ann Intern Med. 128(5), 363-9.
Rajakulasingam, K., et al. (1998) Increased expression of high affinity IgE (FcepsilonRI) receptor-alpha chain mRNA and protein-bearing eosinophils in human allergen-induced atopic asthma. Am J Respir Crit Care Med. 158(1), 233-40.