Rat Toxicology & Drug Resistance

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Oligo GEArray® Rat Toxicology & Drug Resistance Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: ORN-401
HybPlate Format Cat. No.: ERN-401

Description

The Oligo GEArray® Rat Toxicology & Drug Resistance Microarray profiles the expression of 263 genes related to the metabolic processes of cell stress, cell toxicity, drug resistance, and drug metabolism. Genes critical in drug metabolism and resistance such as those encoding enzymes important for drug transport and phase I metabolism (specifically P450-mediated oxidation) are included. Various covalent modification enzymes important for phase II metabolism are also represented. This array includes genes whose expression level is indicative of stress and toxicity as well as those genes representative of pathways activated by prolonged stress. Among these are genes directly up-regulated by oxidative or metabolic stress and genes involved in cell death by apoptosis or necrosis, growth arrest & senescence, and proliferation & carcinogenesis. Genes involved in cellular stress response are also represented, including those encoding DNA repair enzymes, cell cycle regulators, growth factor and hormone receptors, transcription factors, and molecular chaperones. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

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shRNA Plasmids

qPCR Gene Assays

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Functional Gene Grouping

Apoptosis:
Induction of Apoptosis: Atm, Bax, Gpx1, Il18, Mlh1, Myc, Tnf, Tradd.
Anti-apoptosis: Bcl2, Bcl2l1, Hspa1a, Prdx2.
Regulation of Apoptosis: Bcl2l2, Brca1, Casp1, Casp7, Casp8, Ddit3, Mgmt.
Other Genes Involved in Apoptosis: Ahr, Akt1, Bag1, Clu, Dnaja3, E2f1, Gadd45b, Nfkb1, Tnfrsf1a, Tnfsf10, Tnfsf6, Tp53.

Cell Cycle:
Cell Cycle Arrest: Cdkn1a, Cdkn1b, Cdkn2a, Ddit3, Gadd45a, Msh2, Rb1.
Negative Regulation of the Cell Cycle: Apc, Atm, Brca1, Rb1, Tp53.
Regulation of the Cell Cycle: Abl1, Bcr, Brca2, Ccnd1, Cdk4, E2f1, Fgf2, Gadd45b, Il1a, Il1b, Mdm2.
Other Cell Cycle Genes: Ahr, Ccnc, Ccng1, Cdk2, Chek2 (Rad53), Cryaa, Itgb1, Mlh1, Pcna.

Cell Growth and Proliferation:
Chemokines and Cytokines: Ccl3, Ccl4, Csf2, Cxcl10, Gdf15, Il18, Il1a, Il1b, Il6, Lta, Mif, Tnf, Tnfsf10, Tnfsf6.
Growth Factors and Receptors: Ahr, Ar, Arnt, Egfr, Erbb2, Erbb3, Erbb4, Esr1, Esr2, Fgf2, Igf1r, Igf2r, Met, Tnfrsf1a.
Other Genes Related to Growth and Proliferation: Abl1, Brca1, Cdk4, Cdkn1a, Cdkn1b, Fos, Igfbp6, Mdm2, Mt3, Myc, Nfkbia, Nfkbib, Ppard, Tp53.

Drug Related Transporters: Abcb1, Abcb4, Abcc1, Abcc2, Abcc3, Abcc5, Abcc6, Abcg2, Crabp1, Crat, Dpyd, Egfr, Igf2r, Mt3, Nos2, Nr1i3, Pdia3 (Grp58), Por, Rad50, Xdh.

Cell Adhesion Molecules: Calr, Canx, Itga6, Itga7, Itgae, Itgb1, Itgb2, (Cd18), Itgb5.

Chaperones: Bag1, Calr, Canx, Ccl3, Ccl4, CCRP (Dnajc7), Cct2, Cct3, Cct4, Cct5, Cct7, Cct8, Cryab, Cxcl10, Dnaja1, Dnaja2, Dnaja3, Dnaja4, Dnajb1, Dnajb11, Dnajb4, Dnajb5, Dnajb6, Dnajb9, Dnajc4, Dnajc5, Dnajc8, Hsp105, Hspa1a, Hspa2 (Hspt70), Hspa4, Hspa9a, Hspb1, Hspb2, Hspb3, Hspca, Hspcb, Hspd1 (Hsp60), Hspe1, RGD1560574 (Dnajb10), Serpinh1, St13, Tcp1, Tra1.

DNA Repair Genes: Atm, Brca1, Brca2, Ercc1, Ercc3, Mgmt, Mlh1, Msh2, Rad23a, Rad50, Ung, Xpa, Xpc, Xrcc1.

Transcription Factors and Regulators:
Nuclear Receptors: Ahr, Ar, Esr1, Esr2, Nr1i2, Nr1i3, Ppard, Pparg, Rara, Rarb, Rarg, Rxra, Rxrb, Rxrg.
Others: Arnt, Brca1, Brca2, Ccnc, Cdk2, Cdk4, Cdkn2a, Ddit3, E2f1, Egr1, Ercc3, Fos, Hif1a, Hod (GIIg15b), Hsf1, Kcnh8 (Elk1), LOC365510 (Relb), Myc, Myst2, Nfkb1, Ppargc1a, RGD1307189 (Nfkb2), Tp53.

Drug Metabolizing Enzymes:
Acyltransferases: Acat1, Chat, Cml3, Crat, Dlat, Nat1, Nat5.
Methyltransferases: Comt, Hnmt, Mgmt, Nnmt, Tyms.
Sulfotransferases: Chst1, Chst10, Chst2, Chst3, Chst7, Chst8, RGD1561144 (Chst5), Ste, Sult1a1, Sult1b1, Sult1c1 (Sult1a2), Sult1c2, Sult2b1, Sult4a1, Tpst2.
Isomerase: Lta4h, Mif, Pdia3 (Grp58), Tbxas1, Top1, Top2a.
Oxidoreductases: Acadsb, Cat, Cyp11a1, Cyp11b2, Cyp1a1, Cyp1a2, Cyp1b1, Cyp20a1, Cyp24a1, Cyp2a1, Cyp2a3a, Cyp2b15, Cyp2c, Cyp2c13, Cyp2c7 (Cyp2c39), Cyp2c70 (Cyp2c22), Cyp2d13 (Cyp2d3), Cyp2d22, Cyp2e1, Cyp2f2 (Cyp2f1), Cyp3a3, Cyp3a13 (Cyp3a9), Cyp4a12, Cyp4a22 (Cyp4a1), Cyp4b1, Cyp4f2 (Cyp4f14), Cyp7a1, Cyp7b1, Cyp8b1, Dhfr, Dia1, Dpyd, Fmo1, Fmo4, Fmo5, Gpx1, Gpx2, Gsr, Hmox1, Hmox2, Nos2, Nqo1, Por, Prdx1, Prdx2, Ptgs1, Ptgs2, Sod1, Sod2, Tbxas1, Xdh.
Glutathione Peroxidases: Gpx1, Gpx2, Gsta2, Gsta3 (Gsta5), Gsta4, Gstm1, Gstm2, Gstm3, Gstm5, Gsto1, Gstp2, Gstt1, Gstt2, Mgst1.
Others: Bche, Ces1, Ctps, Cyp26b1, Ephx1, Ephx2, Hat1, Hspa5, Hyou1, Maoa, Maob, Mvp, Pon3, Serpine1, Ugt1a6.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

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