Filamin C, gamma
Human actin-binding protein (ABP), also called filamin, crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Filamin has 3 functional domains: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. FLNC encodes the actin-binding protein gamma-filamin. FLNC is one of three related filamin genes, the original member (FLNA) encoding the acting-binding protein of 280 Kd.